ArticleBMC pediatrics2018
Benefits of starting hypothermia treatment within 6 h vs. 6-12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy.
Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Incidence and outcomes of intrapartum-related neonatal encephalopathy in low-income and middle-income countries: a systematic review and meta-analysis.BMJ global health · 2022Pooled it
- Severity of hypoxic ischemic encephalopathy and heart rate variability in neonates: a systematic review.BMC pediatrics · 2019Pooled it
- Therapeutic hypothermia for newborns with hypoxic-ischaemic encephalopathy.The Cochrane database of systematic reviews · 2026Article
- Article
- Neonatal Hypoxic-Ischemic Encephalopathy: From the Limitations of Therapeutic Hypothermia to Precision Intervention.Drug design, development and therapy · 2026Review
- Molecular Hydrogen Affords Similar Neuroprotection to Therapeutic Hypothermia in a Porcine Model of Neonatal Hypoxic-Ischemic Encephalopathy.Antioxidants (Basel, Switzerland) · 2025Article
- Strategy to Identify Infants with Hypoxic Ischemic Encephalopathy for Therapeutic Hypothermia-A Retrospective Audit.Children (Basel, Switzerland) · 2025Article
- Long-Term Neonatal EEG Modeling with DSP and ML for Grading Hypoxic-Ischemic Encephalopathy Injury.Sensors (Basel, Switzerland) · 2025Article
- Association between cerebral oxygen saturation and neurological injury in asphyxiated neonates in a middle-income country: a retrospective cohort study.BMJ paediatrics open · 2025Article
- Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in Sub-Saharan Africa: A scoping review.PloS one · 2025Article
- A biochemical feedback signal for hypothermia treatment for neonatal hypoxic-ischemic encephalopathy: focusing on central nervous system proteins in biofluids.Frontiers in pediatrics · 2024Review
- GluN2B-containing NMDA receptor attenuated neuronal apoptosis in the mouse model of HIBD through inhibiting endoplasmic reticulum stress-activated PERK/eIF2α signaling pathway.Frontiers in molecular neuroscience · 2024Article
- Effectiveness of amplitude-integrated electroencephalography combined with neuron-specific enolase level in predicting neonatal brain injury and prognosis.American journal of translational research · 2024Article
- Progress in Research on Stem Cells in Neonatal Refractory Diseases.Journal of personalized medicine · 2023Review
- [Effect of ligustrazine on hypoxic-ischemic encephalopathy in neonatal rats by regulating autophagy through the PINK1/Parkin pathway].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Therapeutic hypothermia can cause non-infective C-reactive protein elevating.Frontiers in pediatrics · 2023Article
- Process variations between Swiss units treating neonates with hypoxic-ischemic encephalopathy and their effect on short-term outcome.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- The contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasiaTurkish journal of medical sciences · 2021Article
- Peptidomic Analysis of Neonate Umbilical Cord Blood for the Identification of Endogenous Peptides Involved in Hypoxic-Ischemic Encephalopathy.Frontiers in pediatrics · 2021Article
- Prognostic value of amplitude-integrated EEG in neonates with high risk of neurological sequelae.Annals of clinical and translational neurology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been suggested that mild hypothermia treatment of hypoxia-ischemic encephalopathy (HIE) should start within 6 h after HIE, but many children are admitted to the hospital > 6 h, particularly in developing areas. We aimed to determine whether hypothermia treatment could remain effective within 12 h after birth.
methodsAccording to their admission, 152 newborns were enrolled in the < 6 h and 6-12 h after HIE groups. All newborns received conventional treatment combined with mild head hypothermia therapy, according to our routine clinical practice. Some newborns only received conventional treatment (lacking informed consent). All newborns received amplitude-integrated electroencephalography (aEEG) monitoring for 4 h and neuron-specific enolase (NSE) measurement before and after 3 days of therapy.
resultsCompared to the conventional treatment, hypothermia significantly improved the aEEG scores and NSE values in all newborns of the < 6-h group. In the 6-12-h group, the aEEG scores (F = 5.67, P < 0.05) and NSE values (F = 4.98, P < 0.05) were only improved in newborns with moderate HIE. Hypothermia treatment seems to have no effect in newborns with severe HIE after 6 h (P > 0.05). Hypothermia improved the rates of neonatal death and 18-month disability (all P < 0.01).
conclusionsIn newborns with moderate HIE, starting hypothermia therapy < 6 h and 6-12 h after HIE showed curative effects. In those with severe HIE, only starting hypothermia therapy within 6 h showed curative effects.
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