Evidence map›Paper›PMID 29433474›Full record

Observational studyBMC cancer2018

Real-life feasibility of home-based pulmonary rehabilitation in chemotherapy-treated patients with thoracic cancers: a pilot study.

Cecile Olivier, Jean-Marie Grosbois, Alexis B Cortot, Sophie Peres, Christophe Heron, Julie Delourme, Marianne Gierczynski, Anne Hoorelbeke, Arnaud Scherpereel, Olivier Le Rouzic

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06491784 (EXercise TheRApy in Mesothelioma - A Feasibility Study), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06491784 naunknown statusnot on this mapstarted 2024, after this paper: background citation

EXercise TheRApy in Mesothelioma - A Feasibility Study

TypeinterventionalSponsorNHS Greater Glasgow and ClydeRan2024 to 2025Enrolled40ConditionsMesotheliomaArmsExercise Therapy
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Variability and limitations in home-based exercise program descriptions in oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cecile OlivierCHU Lille, Department of Respiratory Diseases, MESOCLIN, Center for Infection and Immunity of Lille (INSERM U1019 - UMR 8204 - Pasteur Institute of Lille), University of Lille, F-59000, Lille, France.
Jean-Marie GrosboisFormAction Santé, F-59840, Pérenchies, France.
Alexis B CortotCHU Lille, Department of Respiratory Diseases, MESOCLIN, Center for Infection and Immunity of Lille (INSERM U1019 - UMR 8204 - Pasteur Institute of Lille), University of Lille, F-59000, Lille, France.
Sophie PeresSantelys Association, F-59120, Loos, France.
Christophe HeronNutrition Department, CHU Lille, F-59000, Lille, France.
Julie DelourmeCHU Lille, Department of Respiratory Diseases, MESOCLIN, Center for Infection and Immunity of Lille (INSERM U1019 - UMR 8204 - Pasteur Institute of Lille), University of Lille, F-59000, Lille, France.
Marianne GierczynskiCHU Lille, Department of Respiratory Diseases, MESOCLIN, Center for Infection and Immunity of Lille (INSERM U1019 - UMR 8204 - Pasteur Institute of Lille), University of Lille, F-59000, Lille, France.
Anne HoorelbekeCHU Lille, Department of Respiratory Diseases, MESOCLIN, Center for Infection and Immunity of Lille (INSERM U1019 - UMR 8204 - Pasteur Institute of Lille), University of Lille, F-59000, Lille, France.
Arnaud ScherpereelCHU Lille, Department of Respiratory Diseases, MESOCLIN, Center for Infection and Immunity of Lille (INSERM U1019 - UMR 8204 - Pasteur Institute of Lille), University of Lille, F-59000, Lille, France. arnaud.scherpereel@chru-lille.fr.ORCID 0000-0002-7607-1863
Olivier Le RouzicCHU Lille, Department of Respiratory Diseases, MESOCLIN, Center for Infection and Immunity of Lille (INSERM U1019 - UMR 8204 - Pasteur Institute of Lille), University of Lille, F-59000, Lille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with advanced lung cancer (LC) or malignant pleural mesothelioma (MPM) exhibit limitation of exercise capacities and alteration of quality of life (QoL) induced by cancer and its treatment. Few studies assessed pulmonary rehabilitation (PR) in these chemotherapy-treated patients, and none evaluated a home-based PR program.

methodsIn this prospective uncontrolled observational pilot study, patients treated by chemotherapy for LC or MPM were screened for a home-based PR program combining exercise training with global cares including therapeutic education and psychosocial management. Feasibility and safety were evaluated by attendance and adherence to PR program. Various exercise tolerance tests, including 6-min walk test (6MWT) and 6-min stepper test (6MST), were performed before and after PR associated with, QoL and psychological assessment (VSRQ and HAD, respectively).

results243 patients were considered eligible but only 71 (60.6 ± 8.8 years) started a PR and 47 completed the program. Refusals to participate were mostly related to lack of motivation whereas withdrawals to PR were related to cancer-related medical issues. No adverse event related to PR was observed. Baseline 6MWT distance was associated with performance status (r = - 0.45, p = 0.001) and mMRC dyspnea scale (r = - 0.49, p < 0.001) but not with lung cancer stage. Post-PR reassessment showed 6MWT stability and 6MST improvement in patients who completed the program. Daily physical activity (p = 0.007) and anxiety (p = 0.02) scores were significantly improved.

conclusionsHome-based PR was feasible and safe in patients with advanced LC or MPM. Exercise capacities stability in patients who completed the PR program suggests that PR might be beneficial. Further studies are warranted to confirm and to improve the potential value of PR in these patients.

Indexed as

Home Care ServicesAgedCombined Modality TherapyExercise TherapyFeasibility StudiesFemaleHumansLung NeoplasmsMaleMesotheliomaMiddle AgedPilot ProjectsPleural NeoplasmsProspective StudiesQuality of LifeTreatment OutcomeChemotherapyLung neoplasmsMesotheliomaPulmonary rehabilitationQuality of life

Identifiers

PMID29433474
PMCPMC5810120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.