Evidence map›Paper›PMID 29433386›Full record

ArticleAIDS care2018

Sexual risk behaviors following circumcision among HIV-positive men in Rakai, Uganda.

Edward Nelson Kankaka, Joseph Ssekasanvu, Jessica Prodger, Dorean Nabukalu, Hadijja Nakawooya, Anthony Ndyanabo, Godfrey Kigozi, Ronald Gray

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Edward Nelson Kankakaa Rakai Health Sciences Program , Rakai , Uganda.
Joseph Ssekasanvua Rakai Health Sciences Program , Rakai , Uganda.
Jessica Prodgerb Department of Epidemiology, Bloomberg School of Public Health , Johns Hopkins University , Baltimore , MD , USA.
Dorean Nabukalua Rakai Health Sciences Program , Rakai , Uganda.
Hadijja Nakawooyaa Rakai Health Sciences Program , Rakai , Uganda.
Anthony Ndyanaboa Rakai Health Sciences Program , Rakai , Uganda.
Godfrey Kigozia Rakai Health Sciences Program , Rakai , Uganda.
Ronald Graya Rakai Health Sciences Program , Rakai , Uganda.

Funding

ARV effects on HIV epidemiology &behaviors Rakai UgandaR01HD050180 · NICHD · JOHNS HOPKINS UNIVERSITY · PI WAWER, MARIA J · 2005 to 2009
$7.8M
Methods for Reducing Spatial Uncertainty and Bias in Disease SurveillanceR01AI102939 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LESSLER, JUSTIN · 2013 to 2017
$4.6M
Enhanced Provision of Male Circumcision for HIV Prevention, Rakai, UgandaU01AI100031 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRAY, RONALD H · 2012 to 2014
$3.2M
HIV Incidence, Transmission Dynamics and Combination HIV Prevention: Rakai UgandaR01AI110324 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRAY, RONALD H · 2014 to 2016
$2.4M
The Problem With Male Sexual/Repro Health:Qualitative/Quantitative Study, UgandaR01HD070769 · NICHD · JOHNS HOPKINS UNIVERSITY · PI WAWER, MARIA J · 2011 to 2013
$1.4M
Male Circumcision and Use of Foreskin Tissues for HIV Prevention in UgandaD43TW009578 · FIC · JOHNS HOPKINS UNIVERSITY · PI GRAY, RONALD H · 2013 to 2017
$1.3M
FIC NIH HHS D43 TW009578NIAID NIH HHS R01 AI102939NIAID NIH HHS R01 AI110324NIAID NIH HHS U01 AI100031NICHD NIH HHS R01 HD050180NICHD NIH HHS R01 HD070769
6 · The paper itself

Abstract

objectiveTo determine whether circumcision of HIV-positive men is associated with increased subsequent sexual risk behaviors which may place their female partners at risk.

methodsNewly circumcised and uncircumcised HIV-positive men in the Rakai Community Cohort Study were followed from baseline (July 2013-January 2015) to determine trend in sexual risk behaviors and association of circumcision with subsequent sexual risk behaviors at follow up (February 2015-September 2016). Risk behaviors included sexual activity, alcohol before sex, transactional sex, multiple sex partners, casual sex partners, and inconsistent condom use with casual partners. The association was evaluated using modified Poisson regression, and sensitivity analyses were performed after multiple imputation with chained equations for missing data.

resultsWe identified 538 eligible men, of whom 113(21.0%) were circumcised at baseline and 425(79.0%) were uncircumcised. Men in fishing communities were more likely to be circumcised (p = 0.032) as well as those exposed to targeted HIV messaging (p < 0.001). Overall, 188(34.9%) men were lost to follow up and most were uncircumcised (p = 0.020). Among those followed up, behaviors remained largely unchanged with no differences by circumcision status. Transactional sex appeared to be associated with circumcision in unadjusted analyses (PR = 1.58, 95%CI = 1.01,2.48; p = 0.045, p = 0.05) and adjusted analyses (adj.PR = 1.54, 95%CI = 1.06,2.23; p = 0.022). However, the association was no longer significant in sensitivity analyses after accounting for loss to follow up (adj.PR = 1.43, 95%CI = 0.98,2.08; p = 0.066). No association with circumcision was observed for other sexual risk behaviors.

conclusionWe found no association between circumcision of HIV-positive men and subsequent sexual risk behavior.

Indexed as

Circumcision, MaleRisk-TakingUnsafe SexAdultCohort StudiesHIV InfectionsHumansMaleSexual PartnersUgandaHIV-positivemale circumcisionRakairisk compensationrisky sexual behavior

Identifiers

PMID29433386
PMCPMC6284241

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.