Evidence map›Paper›PMID 29433357›Full record

ArticleDrug delivery2018

Transferrin and octaarginine modified dual-functional liposomes with improved cancer cell targeting and enhanced intracellular delivery for the treatment of ovarian cancer.

Pranali Deshpande, Aditi Jhaveri, Bhushan Pattni, Swati Biswas, Vladimir Torchilin

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 110 citations in OpenAlex.

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  12. Nano-biotechnology in tumour and cancerous disease: A perspective review.Journal of cellular and molecular medicine · 2023
    Review
  13. New trends in diagnosing and treating ovarian cancer using nanotechnology.Frontiers in bioengineering and biotechnology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Pranali Deshpandea Center for Pharmaceutical Biotechnology and Nanomedicine , Northeastern University , Boston , MA , USA.
Aditi Jhaveria Center for Pharmaceutical Biotechnology and Nanomedicine , Northeastern University , Boston , MA , USA.
Bhushan Pattnia Center for Pharmaceutical Biotechnology and Nanomedicine , Northeastern University , Boston , MA , USA.
Swati Biswasb Department of Pharmacy , Birla Institute of Technology & Science-Pilani, Hyderabad Campus , Hyderabad , India.
Vladimir Torchilina Center for Pharmaceutical Biotechnology and Nanomedicine , Northeastern University , Boston , MA , USA.
Northeastern University · USBirla Institute of Technology and Science, Pilani · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Off-target effects of drugs severely limit cancer therapy. Targeted nanocarriers are promising to enhance the delivery of therapeutics to tumors. Among many approaches for active tumor-targeting, arginine-rich cell penetrating peptides (AR-CPP) and ligands specific to target over-expressed receptors on cancer-cell surfaces, are popular. Earlier, we showed that the attachment of an AR-CPP octaarginine (R8) to the surface of DOXIL

Indexed as

AnimalsCell LineCell Line, TumorCell-Penetrating PeptidesDoxorubicinDrug Delivery SystemsFemaleHumansLiposomesMiceMice, NudeNIH 3T3 CellsOligopeptidesOvarian NeoplasmsPolyethylene GlycolsReceptors, TransferrinCell-Penetrating PeptidesDoxorubicinliposomal doxorubicinLiposomesoctaarginineOligopeptidesPolyethylene GlycolsReceptors, TransferrinTransferrinactive targetingdoxorubicindual-functional liposomesLiposomesoctaarginineovarian cancerTfR over-expressiontransferrin

Identifiers

PMID29433357
PMCPMC6058534
OpenAlexW2791343486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.