Evidence map›Paper›PMID 29432952›Full record

ReviewSeminars in cell & developmental biology2019

G.I. pros: Antimicrobial defense in the gastrointestinal tract.

Lawton K Chung, Manuela Raffatellu

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
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  17. Review
  18. The Klebsiella pneumoniaeInfection and immunity · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lawton K ChungDepartment of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California, San Diego, La Jolla, CA, 92093-0704, United States.
Manuela RaffatelluDepartment of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California, San Diego, La Jolla, CA, 92093-0704, United States; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla CA, United States. Electronic address: manuelar@ucsd.edu.

Funding

Nutritional immunity during Salmonella infectionR01AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAFFATELLU, MANUELA · 2016 to 2020
$1.9M
Development of siderophore-based vaccines against non-typhoidal Salmonella infectionR01AI114625 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2015 to 2019
$1.9M
Nutritional immunity during Salmonella infectionR37AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Manuela Raffatellu · 2023 to 2026
$1.8M
The new chemokine CCL28 and its role during Salmonella infectionR21AI121928 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAFFATELLU, MANUELA, ZLOTNIK, ALBERT · 2016 to 2017
$425k
Siderophore-based antibiotics: consequences for the microbiota and bacterial pathogensR21AI126465 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2016 to 2017
$404k
Harnessing iron acquisition to hinder enterobacterial pathogenesisR56AI114625 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2022 to 2022
$400k
NIAID NIH HHS R01 AI114625NIAID NIH HHS R01 AI126277NIAID NIH HHS R21 AI121928NIAID NIH HHS R21 AI126465NIAID NIH HHS R37 AI126277NIAID NIH HHS R56 AI114625
6 · The paper itself

Abstract

The gastrointestinal tract is a complex environment in which the host immune system interacts with a diverse array of microorganisms, both symbiotic and pathogenic. As such, mobilizing a rapid and appropriate antimicrobial response depending on the nature of each stimulus is crucial for maintaining the balance between homeostasis and inflammation in the gut. Here we focus on the mechanisms by which intestinal antimicrobial peptides regulate microbial communities during dysbiosis and infection. We also discuss classes of bacterial peptides that contribute to reducing enteric pathogen outgrowth. This review aims to provide a comprehensive overview on the interplay of diverse antimicrobial responses with enteric pathogens and the gut microbiota.

Indexed as

AnimalsBacteriocinsCathelicidinsDefensinsDysbiosisGastrointestinal MicrobiomeGastrointestinal TractGene ExpressionHumansImmunity, MucosalInflammationIntestinal MucosaLipocalin-2MuramidaseSymbiosisBacteriocinsCathelicidinsDefensinsLCN2 protein, humanLipocalin-2MuramidaseAntimicrobial peptidesBacteriocinsEnteric pathogensMicrobiotaMicrocinsNutritional immunity

Identifiers

PMID29432952
PMCPMC6087682

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.