Evidence map›Paper›PMID 29432863›Full record

ArticleThe journal of pain2018

Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats.

Pedro Alvarez, Paul G Green, Jon D Levine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pedro AlvarezDepartment of Oral and Maxillofacial Surgery, University of California, San Francisco, California; Division of Neuroscience, University of California, San Francisco, California.
Paul G GreenDivision of Neuroscience, University of California, San Francisco, California; Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, California.
Jon D LevineDepartment of Oral and Maxillofacial Surgery, University of California, San Francisco, California; Division of Neuroscience, University of California, San Francisco, California; Department of Medicine, University of California, San Francisco, California. Electronic address: jon.levine@ucsf.edu.
University of California, San Francisco · US

Funding

Acute-to-Chronic Transition in Ergonomic Muscle Pain: Nociceptor MechanismsR01AR063312 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2013 to 2022
$6.5M
NIAMS NIH HHS R01 AR063312
6 · The paper itself

Abstract

Neonatal handling (NH) of male rat pups strongly attenuates stress response and stress-induced persistent muscle hyperalgesia in adults. Because female sex is a well established risk factor for stress-induced chronic muscle pain, we explored whether NH provides resilience to stress-induced hyperalgesia in adult female rats. Rat pups underwent NH, or standard (control) care. Muscle mechanical nociceptive threshold was assessed before and after water avoidance (WA) stress, when they were adults. In contrast to male rats, NH produced only a modest protection against WA stress-induced muscle hyperalgesia in female rats. Gonadectomy completely abolished NH-induced resilience in male rats but produced only a small increase in this protective effect in female rats. The administration of the antiestrogen drug fulvestrant, in addition to gonadectomy, did not enhance the protective effect of NH in female rats. Finally, knockdown of the androgen receptor by intrathecal antisense treatment attenuated the protective effect of NH in intact male rats. Together, these data indicate that androgens play a key role in NH-induced resilience to WA stress-induced muscle hyperalgesia. PERSPECTIVE: NH induces androgen-dependent resilience to stress-induced muscle pain. Therefore, androgens may contribute to sex differences observed in chronic musculoskeletal pain and its enhancement by stress.

Indexed as

Adaptation, PsychologicalAndrogensAnimalsAnimals, NewbornFemaleHyperalgesiaHypothalamo-Hypophyseal SystemMaleMusculoskeletal PainPain ThresholdPituitary-Adrenal SystemRatsRats, Sprague-DawleySex CharacteristicsStress, PsychologicalAndrogensAndrogenshypothalamic-pituitary-adrenal axismusculoskeletal painnociceptorsex differencestress-induced painwater avoidance stress

Identifiers

PMID29432863
PMCPMC5972068
OpenAlexW2789880400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.