ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2019
Accelerometer Physical Activity is Associated with Greater Gray Matter Volumes in Older Adults Without Dementia or Mild Cognitive Impairment.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Change in Views of Aging, Physical Activity, and Physical Health Over 8 Weeks: Results From a Randomized Study.Journal of aging and physical activity · 2023Trial
- Sensor-measured sedentariness and physical activity are differentially related to fluid and crystallized abilities in aging.Psychology and aging · 2020Trial
- Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study.Journal of Alzheimer's disease : JAD · 2019Trial
- Microstructural Brain Reserve Moderates the Associations Between 24-h Movement Behaviors and Cognition in Older Adults: Cross-Sectional Findings From the AGUEDA Trial.Scandinavian journal of medicine & science in sports · 2026Article
- Physical-Digital and social-nonsocial extracurricular engagement: differential effects on brain development and psychological outcomes in children.Translational psychiatry · 2026Article
- The Impact of Active Augmented Reality Games on Physical Activity and Cognition Among Older Adults: Feasibility Study.JMIR serious games · 2025Article
- 24-hour activity cycle behaviors and gray matter volume in mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Combination of Physical Activity and Cognitive Games is Associated With Better Cognitive Performance and Gray Matter Volume in Older Adults.International journal of geriatric psychiatry · 2025Article
- Associations between physical activity and brain structure in a large community cohort.Scientific reports · 2025Article
- Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle-aged and older adults.Neurobiology of aging · 2025Article
- Data Analytics in Physical Activity Studies With Accelerometers: Scoping Review.Journal of medical Internet research · 2024Article
- Cross-sectional associations between 24-hour time-use composition, grey matter volume and cognitive function in healthy older adults.The international journal of behavioral nutrition and physical activity · 2024Article
- Sex-specific relationships between obesity, physical activity, and gray and white matter volume in cognitively unimpaired older adults.GeroScience · 2023Article
- Ultrasonographic/regional muscle measurements for diagnosing sarcopenia in older adults with and without dementia.Turkish journal of medical sciences · 2022Article
- Association Between Accelerometer-Derived Physical Activity Measurements and Brain Structure: A Population-Based Cohort Study.Neurology · 2022Article
- The association between leisure activity patterns and the prevalence of mild cognitive impairment in community-dwelling older adults.Frontiers in psychology · 2022Article
- Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank.BMC medicine · 2021Article
- Association Between Brain Volumes and Patterns of Physical Activity in Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Prospective Analysis of Leisure-Time Physical Activity in Midlife and Beyond and Brain Damage on MRI in Older Adults.Neurology · 2021Article
- Household physical activity is positively associated with gray matter volume in older adults.BMC geriatrics · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesPhysical activity (PA) is a modifiable health behavior that can protect against age-related gray matter atrophy and cognitive dysfunction. Current studies of PA and gray matter failed to utilize device measures of PA and do not focus on adults >80 years. Thus, the purpose of this secondary analysis was to examine cross-sectional associations between accelerometer lifestyle PA and (a) gray matter volumes and (b) cognitive function, controlling for demographics, and health status.
methodParticipants were 262 older adults without dementia or mild cognitive impairment from Rush Memory and Aging Project, an epidemiological cohort study. Participants wore an accelerometer to assess total daily lifestyle PA, and completed anatomical magnetic resonance imaging to assess gray matter volumes and a neurocognitive test battery to assess cognitive function.
resultsMultivariate linear regression indicated that higher levels of total daily lifestyle PA was significantly related to larger gray matter volumes, F(2, 215) = 3.61, p = .027, including subcortical gray matter (β = 0.17, p = .007) and total gray matter (β = 0.11, p = .049), with no significant associations between lifestyle PA and cognitive function. DISCUSSION: These findings may inform future lifestyle PA interventions in order to attenuate age-related gray matter atrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.