ArticleGenome biology and evolution2018
Fitness Tradeoffs of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli.
Article in Genome biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- RND-mediated efflux couples antimicrobial resistance and hypervirulence in contemporary Vibrio cholerae.PLoS pathogens · 2026Article
- A One Health comparative genomic assessment of antimicrobial-resistantApplied and environmental microbiology · 2026Article
- Sublethal Antibiotic Exposure Induces Microevolution of Quinolone Resistance in PathogenicInternational journal of molecular sciences · 2026Article
- Genomic characterization of multidrug-resistant Escherichia coli isolates from hospital wastewater in Jakarta, Indonesia.Molecular biology reports · 2025Article
- The metabolic burden associated with plasmid acquisition: An assessment of the unrecognized benefits to host cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Major F plasmid clusters are linked with ColV and pUTI89-like marker genes in bloodstream isolates of Escherichia coli.BMC genomics · 2025Article
- Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs.eLife · 2024Article
- SystematicJAC-antimicrobial resistance · 2024Article
- Context-dependent fitness benefits of antibiotic resistance mutations.Proceedings. Biological sciences · 2024Article
- Optimizing bacteriophage treatment of resistantmSphere · 2024Article
- Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs.bioRxiv : the preprint server for biology · 2024Article
- FdeC expression regulates motility and adhesion of the avian pathogenic Escherichia coli strain IMT5155.Veterinary research · 2024Article
- Unpredictability of the Fitness Effects of Antimicrobial Resistance Mutations Across Environments in Escherichia coli.Molecular biology and evolution · 2024Article
- Demographic fluctuations in bloodstreamnpj antimicrobials and resistance · 2024Article
- Biological lessons for strategic resistance management.Evolutionary applications · 2023Article
- Collateral sensitivity profiling in drug-resistant Escherichia coli identifies natural products suppressing cephalosporin resistance.Nature communications · 2023Article
- Bacterial volatile organic compounds attenuate pathogen virulence via evolutionary trade-offs.The ISME journal · 2023Article
- Synergy between Human Peptide LL-37 and Polymyxin B against Planktonic and Biofilm Cells ofAntibiotics (Basel, Switzerland) · 2023Article
- Adaptation ofMicrobiology (Reading, England) · 2023Article
- Within-patient evolution of plasmid-mediated antimicrobial resistance.Nature ecology & evolution · 2022Article
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Authors and funding
9 authors.
Funding
Abstract
Evolutionary trade-offs occur when selection on one trait has detrimental effects on other traits. In pathogenic microbes, it has been hypothesized that antibiotic resistance trades off with fitness in the absence of antibiotic. Although studies of single resistance mutations support this hypothesis, it is unclear whether trade-offs are maintained over time, due to compensatory evolution and broader effects of genetic background. Here, we leverage natural variation in 39 extraintestinal clinical isolates of Escherichia coli to assess trade-offs between growth rates and resistance to fluoroquinolone and cephalosporin antibiotics. Whole-genome sequencing identifies a broad range of clinically relevant resistance determinants in these strains. We find evidence for a negative correlation between growth rate and antibiotic resistance, consistent with a persistent trade-off between resistance and growth. However, this relationship is sometimes weak and depends on the environment in which growth rates are measured. Using in vitro selection experiments, we find that compensatory evolution in one environment does not guarantee compensation in other environments. Thus, even in the face of compensatory evolution and other genetic background effects, resistance may be broadly costly, supporting the use of drug restriction protocols to limit the spread of resistance. Furthermore, our study demonstrates the power of using natural variation to study evolutionary trade-offs in microbes.
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