ArticleBrain : a journal of neurology2018
Brain tissue plasticity: protein synthesis rates of the human brain.
Article in Brain : a journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
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- Frontotemporal disorders: the expansive panoply of syndromes and spectrum of etiologies.Frontiers in neurology · 2023Article
- An evidence-based critical review of the mind-brain identity theory.Frontiers in psychology · 2023Article
- Is the Brain Undernourished in Alzheimer's Disease?Nutrients · 2022Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- Basal protein synthesis rates differ between vastus lateralis and rectus abdominis muscle.Journal of cachexia, sarcopenia and muscle · 2021Article
- Clinical application of intrathecal gadobutrol for assessment of cerebrospinal fluid tracer clearance to blood.JCI insight · 2021Article
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding.Nutrients · 2020Article
- Proteomic Techniques to Examine Neuronal Translational Dynamics.International journal of molecular sciences · 2019Review
- The Muscle Protein Synthetic Response to Meal Ingestion Following Resistance-Type Exercise.Sports medicine (Auckland, N.Z.) · 2019Review
- Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans.PloS one · 2019Article
- Measurement of regional rates of protein synthesis in human brain in vivo with L-[1-11C]-leucine PET.Brain : a journal of neurology · 2018Article
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11 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
All tissues undergo continuous reconditioning via the complex orchestration of changes in tissue protein synthesis and breakdown rates. Skeletal muscle tissue has been well studied in this regard, and has been shown to turnover at a rate of 1-2% per day in vivo in humans. Few data are available on protein synthesis rates of other tissues. Because of obvious limitations with regard to brain tissue sampling no study has ever measured brain protein synthesis rates in vivo in humans. Here, we applied stable isotope methodology to directly assess protein synthesis rates in neocortex and hippocampus tissue of six patients undergoing temporal lobectomy for drug-resistant temporal lobe epilepsy (Clinical trial registration: NTR5147). Protein synthesis rates of neocortex and hippocampus tissue averaged 0.17 ± 0.01 and 0.13 ± 0.01%/h, respectively. Brain tissue protein synthesis rates were 3-4-fold higher than skeletal muscle tissue protein synthesis rates (0.05 ± 0.01%/h; P < 0.001). In conclusion, the protein turnover rate of the human brain is much higher than previously assumed.
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