ArticleGigaScience2018
Advanced lesion symptom mapping analyses and implementation as BCBtoolkit.
Article in GigaScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 196 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
196 citing papers in PubMed, 4 syntheses or guidelines pooled it, 371 citations in OpenAlex.
- Topography and functional connectivity analysis of heart surgery-associated brain lesions: a literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- A probabilistic map of motor and cognitive functions: a meta-analysis of 4325 stimulation sites.Brain structure & function · 2025Pooled it
- Pooled it
- White matter variability, cognition, and disorders: a systematic review.Brain structure & function · 2022Pooled it
- The relevance of rich club regions for functional outcome post-stroke is enhanced in women.Human brain mapping · 2023Trial
- Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study.Scientific reports · 2021Trial
- Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke.Nature communications · 2021Trial
- Investigating the Neural Bases of Egocentric Spatial Reference Frame After Right-Hemisphere Stroke: Brain Lesions and Disconnectome Analyses of Subjective Straight Ahead and Longitudinal Body Axis Misperception.Human brain mapping · 2026Observational
- Harmonized Acquisition of Connectome MRI and Clinical Data for Stroke, Parkinson's Disease and Glioma: Delphi-Derived Protocol Recommendations by the European Academy of Neurology.European journal of neurology · 2026Review
- Article
- Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects.Research square · 2026Article
- Longitudinal Degeneration of Microstructural and Structural Connectivity Patterns Following Stroke.Stroke · 2026Article
- Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects.bioRxiv : the preprint server for biology · 2026Article
- Inside the frontal face network: multimodal evidence for distinct emotional and motor resonance circuits.Brain structure & function · 2026Article
- Acute-Phase Machine Learning Prediction of 12-Month Aphasia and Discourse Recovery.medRxiv : the preprint server for health sciences · 2026Article
- A deep representation learning model to predict response to vagus nerve stimulation.Nature communications · 2026Article
- Understanding the unmet needs of patients with brain metastases referred for stereotactic radiotherapy and their caregivers: A prospective cohort study.Neuro-oncology practice · 2026Article
- Post-stroke motivational decline was associated with lesions in the left deep white matter involving the corticospinal tract and superior longitudinal fasciculus.Brain imaging and behavior · 2026Article
- Pulvinar-posterior superior temporal sulcus connectivity contributes to non-conscious emotion processing in affective blindsight.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Patterns of Structural Disconnection Driving Proprioceptive Deficits in Chronic Stroke.Stroke · 2026Observational
136 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Patients with brain lesions provide a unique opportunity to understand the functioning of the human mind. However, even when focal, brain lesions have local and remote effects that impact functionally and structurally connected circuits. Similarly, function emerges from the interaction between brain areas rather than their sole activity. For instance, category fluency requires the associations between executive, semantic, and language production functions. Findings: Here, we provide, for the first time, a set of complementary solutions for measuring the impact of a given lesion on the neuronal circuits. Our methods, which were applied to 37 patients with a focal frontal brain lesions, revealed a large set of directly and indirectly disconnected brain regions that had significantly impacted category fluency performance. The directly disconnected regions corresponded to areas that are classically considered as functionally engaged in verbal fluency and categorization tasks. These regions were also organized into larger directly and indirectly disconnected functional networks, including the left ventral fronto-parietal network, whose cortical thickness correlated with performance on category fluency. Conclusions: The combination of structural and functional connectivity together with cortical thickness estimates reveal the remote effects of brain lesions, provide for the identification of the affected networks, and strengthen our understanding of their relationship with cognitive and behavioral measures. The methods presented are available and freely accessible in the BCBtoolkit as supplementary software [1].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.