Evidence map›Paper›PMID 29432186›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Adaptive antibody diversification through

Fleur S van de Bovenkamp, Ninotska I L Derksen, Pleuni Ooijevaar-de Heer, Karin A van Schie, Simone Kruithof, Magdalena A Berkowska, C Ellen van der Schoot, Hanna IJspeert, Mirjam van der Burg, Ann Gils and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Altered IgGBiomedicines · 2025
    Article
  12. Article
  13. Article
  14. Role of Antibody Glycosylation in Health, Disease, and Therapy.Handbook of experimental pharmacology · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. B Cell Responses to the Placenta and Fetus.Annual review of pathology · 2025
    Review
  19. Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Fleur S van de BovenkampSanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands; s.vandebovenkamp@sanquin.nl.
Ninotska I L DerksenSanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
Pleuni Ooijevaar-de HeerSanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
Karin A van SchieSanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
Simone KruithofSanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
Magdalena A BerkowskaSanquin Research, Department of Experimental Immunohematology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
C Ellen van der SchootSanquin Research, Department of Experimental Immunohematology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
Hanna IJspeertErasmus Medical Center, Department of Immunology, University Medical Center Rotterdam, 3015 CE, Rotterdam, The Netherlands.
Mirjam van der BurgErasmus Medical Center, Department of Immunology, University Medical Center Rotterdam, 3015 CE, Rotterdam, The Netherlands.
Ann GilsLaboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000 Belgium.
Lise HafkenscheidDepartment of Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
René E M ToesDepartment of Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Yoann RomboutsDepartment of Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.ORCID 0000-0003-4482-2199
Rosina PlompCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Manfred WuhrerCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
S Marieke van HamSanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
Gestur VidarssonSanquin Research, Department of Experimental Immunohematology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
Theo RispensSanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
Sanquin · NLLeiden University Medical Center · NLCentre National de la Recherche Scientifique · FRErasmus MC · NLKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A hallmark of B-cell immunity is the generation of a diverse repertoire of antibodies from a limited set of germline V(D)J genes. This repertoire is usually defined in terms of amino acid composition. However, variable domains may also acquire

Indexed as

AntibodiesAntibodies, MonoclonalAntibody AffinityArthritis, RheumatoidAutoantibodiesB-LymphocytesGlycosylationHumansImmunoglobulin GImmunoglobulin Variable RegionAntibodiesAntibodies, MonoclonalAutoantibodiesImmunoglobulin GImmunoglobulin Variable Regionantibody diversificationFab glycosylationvariable domain glycosylation

Identifiers

PMID29432186
PMCPMC5828577
OpenAlexW2789361433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.