Evidence map›Paper›PMID 29432175›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Uterine influences on conceptus development in fertility-classified animals.

Joao G N Moraes, Susanta K Behura, Thomas W Geary, Peter J Hansen, Holly L Neibergs, Thomas E Spencer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 144 citations in OpenAlex.

  1. Review
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  4. PGEAnimals : an open access journal from MDPI · 2026
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Joao G N MoraesDivision of Animal Sciences, University of Missouri, Columbia, MO 65211.
Susanta K BehuraDivision of Animal Sciences, University of Missouri, Columbia, MO 65211.
Thomas W GearyFort Keogh Livestock and Range Research Laboratory, United States Department of Agriculture Agricultural Research Service, Miles City, MT 59301.
Peter J HansenDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611.ORCID 0000-0003-3061-9333
Holly L NeibergsDepartment of Animal Sciences, Washington State University, Pullman, WA 99164.
Thomas E SpencerDivision of Animal Sciences, University of Missouri, Columbia, MO 65211; spencerte@missouri.edu.
University of Missouri · USAgricultural Research Service · USUniversity of Florida · USWashington State University · US

Funding

Systems biology approach to understand endometrial receptivity & pregnancy lossR01HD072898 · NICHD · WASHINGTON STATE UNIVERSITY · PI SPENCER, THOMAS E · 2012 to 2016
$1.1M
NICHD NIH HHS R01 HD072898
6 · The paper itself

Abstract

A major unresolved issue is how the uterus influences infertility and subfertility in cattle. Serial embryo transfer was previously used to classify heifers as high-fertile (HF), subfertile (SF), or infertile (IF). To assess pregnancy loss, two in vivo-produced embryos were transferred into HF, SF, and IF heifers on day 7, and pregnancy outcome was assessed on day 17. Pregnancy rate was substantially higher in HF (71%) and SF (90%) than IF (20%) heifers. Elongating conceptuses were about twofold longer in HF than SF heifers. Transcriptional profiling detected relatively few differences in the endometrium of nonpregnant HF, SF, and IF heifers. In contrast, there was a substantial difference in the transcriptome response of the endometrium to pregnancy between HF and SF heifers. Considerable deficiencies in pregnancy-dependent biological pathways associated with extracellular matrix structure and organization as well as cell adhesion were found in the endometrium of SF animals. Distinct gene expression differences were also observed in conceptuses from HF and SF animals, with many of the genes decreased in SF conceptuses known to be embryonic lethal in mice due to defects in embryo and/or placental development. Analyses of biological pathways, key players, and ligand-receptor interactions based on transcriptome data divulged substantial evidence for dysregulation of conceptus-endometrial interactions in SF animals. These results support the ideas that the uterus impacts conceptus survival and programs conceptus development, and ripple effects of dysregulated conceptus-endometrial interactions elicit loss of the postelongation conceptus in SF cattle during the implantation period of pregnancy.

Indexed as

Cattle DiseasesInfertility, FemaleAnimalsCattleEmbryonic DevelopmentEmbryo TransferEndometriumFemalePregnancyPregnancy RateTranscriptomeconceptusendometriumfertilitygene expressionpregnancy

Identifiers

PMID29432175
PMCPMC5828633
OpenAlexW2790798210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.