Evidence map›Paper›PMID 29432146›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Bacteriocyte cell death in the pea aphid/

Pierre Simonet, Karen Gaget, Séverine Balmand, Mélanie Ribeiro Lopes, Nicolas Parisot, Kurt Buhler, Gabrielle Duport, Veerle Vulsteke, Gérard Febvay, Abdelaziz Heddi and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 86 citations in OpenAlex.

  1. A transcription factor regulates development of a bacteria-housing eukaryotic cell through DNA damage mitigation.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  5. Fidelity in co-diversified symbiosis.Nature communications · 2026
    Article
  6. Heritable viral symbionts in the familyApplied and environmental microbiology · 2025
    Article
  7. Article
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  11. A complete DNA repair system assembled by two endosymbionts restores heat tolerance of the insect host.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
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  20. A novel geneeLife · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Pierre SimonetUMR0203, Biologie Fonctionnelle, Insectes et Interactions BF2I, Institut National des Sciences Appliquées (INSA-Lyon), Institut National de la Recherche Agronomique (INRA), University of Lyon, F-69621 Villeurbanne, France; pierre.simonet@insa-lyon.fr federica.calevro@insa-lyon.fr.
Karen GagetUMR0203, Biologie Fonctionnelle, Insectes et Interactions BF2I, Institut National des Sciences Appliquées (INSA-Lyon), Institut National de la Recherche Agronomique (INRA), University of Lyon, F-69621 Villeurbanne, France.
Séverine BalmandUMR0203, Biologie Fonctionnelle, Insectes et Interactions BF2I, Institut National des Sciences Appliquées (INSA-Lyon), Institut National de la Recherche Agronomique (INRA), University of Lyon, F-69621 Villeurbanne, France.
Mélanie Ribeiro LopesUMR0203, Biologie Fonctionnelle, Insectes et Interactions BF2I, Institut National des Sciences Appliquées (INSA-Lyon), Institut National de la Recherche Agronomique (INRA), University of Lyon, F-69621 Villeurbanne, France.
Nicolas ParisotUMR0203, Biologie Fonctionnelle, Insectes et Interactions BF2I, Institut National des Sciences Appliquées (INSA-Lyon), Institut National de la Recherche Agronomique (INRA), University of Lyon, F-69621 Villeurbanne, France.
Kurt BuhlerLaboratory of Behavioral and Developmental Genetics, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, University of Leuven, B-3000 Leuven, Belgium.
Gabrielle DuportUMR0203, Biologie Fonctionnelle, Insectes et Interactions BF2I, Institut National des Sciences Appliquées (INSA-Lyon), Institut National de la Recherche Agronomique (INRA), University of Lyon, F-69621 Villeurbanne, France.
Veerle VulstekeLaboratory of Behavioral and Developmental Genetics, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, University of Leuven, B-3000 Leuven, Belgium.
Gérard FebvayUMR0203, Biologie Fonctionnelle, Insectes et Interactions BF2I, Institut National des Sciences Appliquées (INSA-Lyon), Institut National de la Recherche Agronomique (INRA), University of Lyon, F-69621 Villeurbanne, France.ORCID 0000-0002-0654-2340
Abdelaziz HeddiUMR0203, Biologie Fonctionnelle, Insectes et Interactions BF2I, Institut National des Sciences Appliquées (INSA-Lyon), Institut National de la Recherche Agronomique (INRA), University of Lyon, F-69621 Villeurbanne, France.
Hubert CharlesUMR0203, Biologie Fonctionnelle, Insectes et Interactions BF2I, Institut National des Sciences Appliquées (INSA-Lyon), Institut National de la Recherche Agronomique (INRA), University of Lyon, F-69621 Villeurbanne, France.
Patrick CallaertsLaboratory of Behavioral and Developmental Genetics, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, University of Leuven, B-3000 Leuven, Belgium.
Federica CalevroUMR0203, Biologie Fonctionnelle, Insectes et Interactions BF2I, Institut National des Sciences Appliquées (INSA-Lyon), Institut National de la Recherche Agronomique (INRA), University of Lyon, F-69621 Villeurbanne, France; pierre.simonet@insa-lyon.fr federica.calevro@insa-lyon.fr.
Université Claude Bernard Lyon 1 · FRKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Symbiotic associations play a pivotal role in multicellular life by facilitating acquisition of new traits and expanding the ecological capabilities of organisms. In insects that are obligatorily dependent on intracellular bacterial symbionts, novel host cells (bacteriocytes) or organs (bacteriomes) have evolved for harboring beneficial microbial partners. The processes regulating the cellular life cycle of these endosymbiont-bearing cells, such as the cell-death mechanisms controlling their fate and elimination in response to host physiology, are fundamental questions in the biology of symbiosis. Here we report the discovery of a cell-death process involved in the degeneration of bacteriocytes in the hemipteran insect

Indexed as

AnimalsAphidsBuchneraCell DeathLysosomesSymbiosisAcyrthosiphon pisumbacteriocytesBuchnera aphidicolacell deathsymbiosis

Identifiers

PMID29432146
PMCPMC5828623
OpenAlexW2790398905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.