Evidence map›Paper›PMID 29431870›Full record

ArticleClinical and experimental immunology2018

A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study.

A Kozhakhmetova, R C Wyatt, C Caygill, C Williams, A E Long, K Chandler, R J Aitken, J M Wenzlau, H W Davidson, K M Gillespie and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  8. Review
  9. B-Cell Receptor Repertoire: Recent Advances in Autoimmune Diseases.Clinical reviews in allergy & immunology · 2024
    Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

A KozhakhmetovaDiabetes and Metabolism, Translational Health Sciences, University of Bristol, Bristol, UK.
R C WyattDiabetes and Metabolism, Translational Health Sciences, University of Bristol, Bristol, UK.
C CaygillDiabetes and Metabolism, Translational Health Sciences, University of Bristol, Bristol, UK.
C WilliamsDiabetes and Metabolism, Translational Health Sciences, University of Bristol, Bristol, UK.
A E LongDiabetes and Metabolism, Translational Health Sciences, University of Bristol, Bristol, UK.
K ChandlerDiabetes and Metabolism, Translational Health Sciences, University of Bristol, Bristol, UK.
R J AitkenDiabetes and Metabolism, Translational Health Sciences, University of Bristol, Bristol, UK.
J M WenzlauThe Barbara Davis Center for Diabetes, University of Colorado, Denver, CO, USA.
H W DavidsonThe Barbara Davis Center for Diabetes, University of Colorado, Denver, CO, USA.
K M GillespieDiabetes and Metabolism, Translational Health Sciences, University of Bristol, Bristol, UK.ORCID 0000-0002-3009-8032
A J K WilliamsDiabetes and Metabolism, Translational Health Sciences, University of Bristol, Bristol, UK.
University of Bristol · GBUniversity of Colorado Denver · US

Funding

MOLECULAR TARGETS OF CMI IN TYPE I DIABETESR01DK052068 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DAVIDSON, HOWARD W · 1997 to 2014
$3.1M
NIDDK NIH HHS R01 DK052068
6 · The paper itself

Abstract

Individuals with type 1 diabetes (T1D) are at increased risk of coeliac disease (CD), autoimmune thyroiditis and autoimmune gastritis, but the absolute risks are unclear. The aim of this study was to investigate the prevalence of autoantibodies to tissue transglutaminase (TGA), thyroid peroxidase (TPOA) and gastric H

Indexed as

AdolescentAdultAutoantibodiesAutoantigensAutoimmunityCeliac DiseaseChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGenetic Predisposition to DiseaseGlutamate DecarboxylaseGTP-Binding ProteinsH(+)-K(+)-Exchanging ATPaseHLA-DQ AntigensHLA-DR3 AntigenAutoantibodiesAutoantigensGlutamate DecarboxylaseGTP-Binding ProteinsH(+)-K(+)-Exchanging ATPaseHLA-DQ2 antigenHLA-DQ AntigensHLA-DR3 AntigenIodide PeroxidaseIron-Binding ProteinsProtein Glutamine gamma Glutamyltransferase 2TPO protein, humanTransglutaminasesgastric H+/K+-ATPase antibodiesHLAthyroid peroxidase antibodiestissue transglutaminase antibodiestype 1 diabetes

Identifiers

PMID29431870
PMCPMC5980499
OpenAlexW2793413380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.