Evidence map›Paper›PMID 29431742›Full record

ArticleNature medicine2018

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.

Tamer Sallam, Marius Jones, Brandon J Thomas, Xiaohui Wu, Thomas Gilliland, Kevin Qian, Ascia Eskin, David Casero, Zhengyi Zhang, Jaspreet Sandhu and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 1 synthesis or guideline pooled it, 266 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Long Non-coding RNA Based Therapy for Cardiovascular Disease.Journal of cardiovascular translational research · 2025
    Review
  16. Research Status and Latest Progress in the Regulatory Mechanisms of ABCA1.International journal of molecular sciences · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Advances in the Regulation of Lipid Metabolism by Non-Coding RNAs.Animals : an open access journal from MDPI · 2025
    Review

98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 2 countries.

Tamer SallamDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Marius JonesDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Brandon J ThomasDepartment of Microbiology, Immunology, and Molecular Genetics and Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Xiaohui WuDepartment of Medicine, Division of Cardiology, University of California Los Angeles, Los Angeles, California, USA.
Thomas GillilandDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Kevin QianDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Ascia EskinDepartement of Human Genetics, University of California Los Angeles, Los Angeles, California, USA.
David CaseroDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-7347-3330
Zhengyi ZhangDepartment of Medicine, Division of Cardiology, University of California Los Angeles, Los Angeles, California, USA.
Jaspreet SandhuDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
David SalisburyDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Prashant RajbhandariDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Mete CivelekCenter for Public Health Genomics and Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
Cynthia HongDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Ayaka ItoDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Xin LiuDepartment of Microbiology, Immunology, and Molecular Genetics and Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Bence DanielSanford-Burnham-Prebys Medical Discovery Institute at Lake Nona and Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Orlando, Florida, USA.
Aldons J LusisDepartment of Medicine, Division of Cardiology, University of California Los Angeles, Los Angeles, California, USA.
Julian WhiteleggePasarow Mass Spectrometry Laboratory, UCLA Neuropsychiatric Institute (NPI)-Semel Institute, University of California Los Angeles, Los Angeles, California, USA.
Laszlo NagySanford-Burnham-Prebys Medical Discovery Institute at Lake Nona and Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Orlando, Florida, USA.ORCID 0000-0001-6653-2155
Antonio CastrilloInstituto de Investigaciones Biomédicas Alberto Sols, CSIC, Universidad Autónoma de Madrid, Unidad de Biomedicina-Universidad de Las Palmas de Gran Canaria (Unidad asociada al CSIC), Las Palmas de Gran Canaria, Spain.
Stephen SmaleDepartment of Microbiology, Immunology, and Molecular Genetics and Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Peter TontonozDepartment of Pathology and Laboratory Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · USSanford Burnham Prebys Medical Discovery Institute · USHouse Clinic · USUniversidad de Las Palmas de Gran Canaria · ESUniversity of Virginia · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 1985 to 2019
$55.2M
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
NUCLEAR RECEPTOR SIGNALING PATHWAYS IN ATHEROGENESISR01HL066088 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TONTONOZ, PETER J · 2001 to 2018
$5.4M
RNA-binding proteins in atherosclerosisR01HL139549 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tamer Sallam · 2018 to 2026
$3.3M
Long Non-coding RNAs in Cardiometabolic DiseaseK08HL128822 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SALLAM, TAMER · 2015 to 2019
$884k
American Heart Association-American Stroke Association 13POST17080115NHLBI NIH HHS K08 HL128822NHLBI NIH HHS P01 HL030568NHLBI NIH HHS R01 HL066088NHLBI NIH HHS R01 HL139549
6 · The paper itself

Abstract

Nuclear receptors regulate gene expression in response to environmental cues, but the molecular events governing the cell type specificity of nuclear receptors remain poorly understood. Here we outline a role for a long noncoding RNA (lncRNA) in modulating the cell type-specific actions of liver X receptors (LXRs), sterol-activated nuclear receptors that regulate the expression of genes involved in cholesterol homeostasis and that have been causally linked to the pathogenesis of atherosclerosis. We identify the lncRNA MeXis as an amplifier of LXR-dependent transcription of the gene Abca1, which is critical for regulation of cholesterol efflux. Mice lacking the MeXis gene show reduced Abca1 expression in a tissue-selective manner. Furthermore, loss of MeXis in mouse bone marrow cells alters chromosome architecture at the Abca1 locus, impairs cellular responses to cholesterol overload, and accelerates the development of atherosclerosis. Mechanistic studies reveal that MeXis interacts with and guides promoter binding of the transcriptional coactivator DDX17. The identification of MeXis as a lncRNA modulator of LXR-dependent gene expression expands understanding of the mechanisms underlying cell type-selective actions of nuclear receptors in physiology and disease.

Indexed as

AnimalsAtherosclerosisATP Binding Cassette Transporter 1Bone Marrow CellsCholesterolDEAD-box RNA HelicasesGene Expression RegulationHumansLiver X ReceptorsMacrophagesMicePromoter Regions, GeneticRNA, Long NoncodingTranscription, GeneticAbca1 protein, mouseATP Binding Cassette Transporter 1CholesterolDdx17 protein, mouseDEAD-box RNA HelicasesLiver X ReceptorsRNA, Long Noncoding

Identifiers

PMID29431742
PMCPMC5839972
OpenAlexW2790187710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.