Observational studyJournal of immunology (Baltimore, Md. : 1950)2018
Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment.
Registry-linked trialOpen access · bronzeAbstract readObservational Study
In one paragraph
Observational study in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00114881 (Urban Environment and Childhood Asthma), which is not on this map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urban Environment and Childhood Asthma (URECA)
Who cites it
36 citing papers in PubMed, 44 citations in OpenAlex.
- Review
- Article
- The Role of Innate T Cells in Inflammatory Disorders in Asthma and Chronic Rhinosinusitis.Clinical and experimental otorhinolaryngology · 2026Review
- Alleviation of Chitin- and Ovalbumin-Induced Steroid-Resistant Eosinophilic Airway Inflammation Associated with NLRP3 Axis Inhibition in a Mouse Model.Journal of inflammation research · 2026Article
- Estrogen Induced Regulation of Mucosal-Associated Invariant T Cells in Asthma.Journal of immunology research · 2026Article
- Dual role of mucosal-associated invariant T cells (MAIT) in asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2025Review
- MAIT cells modulating the oral lichen planus immune microenvironment: a cellular crosstalk perspective.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Mucosal associated invariant T cells: Powerhouses of the lung.Immunology letters · 2024Review
- Evaluation of the association of mucosa-associated invariant T (MAIT) cells with childhood asthma.Turkish journal of medical sciences · 2024Article
- Development of systemic and mucosal immune responses against gut microbiota in early life and implications for the onset of allergies.Frontiers in allergy · 2024Review
- Transcriptomes and metabolism define mouse and human MAIT cell populations.Science immunology · 2023Article
- MAIT cells and the microbiome.Frontiers in immunology · 2023Review
- T-cell responses in asthma exacerbations.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Review
- The role of unconventional T cells in maintaining tissue homeostasis.Seminars in immunology · 2022Review
- Gut Microbiota-Derived Unconventional T Cell Ligands: Contribution to Host Immune Modulation.ImmunoHorizons · 2022Article
- Mucosal-associated invariant T cells repress group 2 innate lymphoid cells inFrontiers in immunology · 2022Article
- Repetitive aeroallergen challenges elucidate maladaptive epithelial and inflammatory traits that underpin allergic airway diseases.The Journal of allergy and clinical immunology · 2021Observational
- Does exercise attenuate age- and disease-associated dysfunction in unconventional T cells? Shining a light on overlooked cells in exercise immunology.European journal of applied physiology · 2021Review
- A rich meconium metabolome in human infants is associated with early-life gut microbiota composition and reduced allergic sensitization.Cell reports. Medicine · 2021Article
- Title of article: Mucosal-associated invariant T cells in lung diseases.International immunopharmacology · 2021Review
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 2 countries.
Shilpi ChandraDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.
Gerhard WingenderDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.
Jason A GreenbaumBioinformatics Core Facility, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.ORCID 0000-0002-1381-0390
Archana KhuranaDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.
Amin M GholamiBioinformatics Core Facility, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037.ORCID 0000-0002-5924-219X
Anusha-Preethi GanesanDivision of Pediatric Hematology-Oncology, Rady Children's Hospital, University of California San Diego, San Diego, CA 92093.ORCID 0000-0003-3775-9996
Michael RosenbachDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Katy JaffeeDivision of Federal Systems, Rho Inc., Chapel Hill, NC 27517.
James E GernDepartment of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726.ORCID 0000-0002-6667-4708
Robert WoodDivision of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 212876.
George O'ConnorDepartment of Medicine, Boston University School of Medicine, Boston, MA 02118.
Megan SandelDepartment of Medicine, Boston University School of Medicine, Boston, MA 02118.ORCID 0000-0001-7324-6325
Meyer KattanDivision of Pediatric Pulmonology, Department of Pediatrics, New York Presbyterian/Columbia University Medical Center, New York, NY 10032.
Leonard BacharierDivision of Allergy, Immunology, and Pulmonary Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Alkis TogiasNational Institutes of Health, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852; and.ORCID 0000-0001-9009-5717
Anthony A HornerDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Mitchell KronenbergDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; mitch@lji.org.ORCID 0000-0001-6318-6445
La Jolla Institute for Immunology · USBoston University · USUniversity of California San Diego · USColumbia University Irving Medical Center · USJohns Hopkins University · USNational Institutes of Health · USRho (United States) · USUniversity of Wisconsin–Madison · USWashington University in St. Louis · US
Funding
Transplantation GroupUM2AI117870 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI DAVID, GLORIA · 2015 to 2023
$208.1MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MInner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0MWashington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4MZIPRASIDONE (GEODON) AUGMENTATION IN SEROTONIN REUPTAKE INHIBITOR-RESISTANT OBM01RR000071 · NCRR · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GOODMAN, MARC T · 1985 to 2009
$41.5MZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MARSH, LAURA · 1985 to 2007
$37.3MYOGA INDUCED CHANGES IN BRAIN GABA LEVELSM01RR000533 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HOLICK, MICHAEL F. · 1985 to 2008
$19.4MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025771 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CENTER, DAVID M. · 2008 to 2011
$17.6MRESEARCH TRAINING IN PEDIATRIC ALLERGY &IMMUNOLOGYT32AI007007 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ROBERT A WOOD · 1985 to 2026
$5.4MDevelopment and Function of NKT CellsR37AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2006 to 2015
$4.9MDifferentiation of subsets of NKT cellsR01AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2016 to 2020
$2.7MNCATS NIH HHS UL1 TR002345NCRR NIH HHS M01 RR000052NCRR NIH HHS M01 RR000071NCRR NIH HHS M01 RR000533NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR024992NCRR NIH HHS UL1 RR025771NIAID NIH HHS HHSN272201000052INIAID NIH HHS N01 AI025482NIAID NIH HHS N01 AI025496NIAID NIH HHS R01 AI071922NIAID NIH HHS R01 AI105215NIAID NIH HHS R37 AI071922NIAID NIH HHS T32 AI007007NIAID NIH HHS UM1 AI114271NIAID NIH HHS UM2 AI117870
Abstract
Humans have populations of innate-like T lymphocytes with an invariant TCR α-chain that recognize nonpeptide Ags, including invariant NKT (iNKT) cells and mucosal-associated invariant T (MAIT) cells. iNKT cell involvement in human asthma is controversial, whereas there has been little analysis of MAIT cells. Using peripheral blood cells from 110 participants from the Urban Environment and Childhood Asthma (URECA) birth cohort study, these cells were analyzed for number and function. We determined whether iNKT cell or MAIT cell frequency at 1 y is correlated with the cytokine polarization of mainstream CD4
Indexed as
AsthmaCD4-Positive T-LymphocytesChildChild, PreschoolCitiesCohort StudiesDustEnvironmentFemaleHumansInfantInterferon-gammaLymphocyte ActivationLymphocyte CountMaleMucosal-Associated Invariant T CellsDustInterferon-gamma
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT00114881ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.