ArticleCancer discovery2018
A Critical Need for Better Cancer Immunotherapy Models: Are Organotypic Tumor Spheroid Cultures the Answer?
Article in Cancer discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- BIOPRINTING OF MICRODISSECTED TUMOR "CUBOIDS" IN HYDROGELS.bioRxiv : the preprint server for biology · 2025Article
- Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine.Journal of personalized medicine · 2022Review
- The future of microfluidics in immune checkpoint blockade.Cancer gene therapy · 2021Review
- Establishment of patient-derived organotypic tumor spheroid models for tumor microenvironment modeling.Cancer medicine · 2021Article
- Microdissected "cuboids" for microfluidic drug testing of intact tissues.Lab on a chip · 2021Article
- Combination Therapy with iRGD-antiCD3 and PD-1 Blockade Enhances Antitumor Potency of Cord Blood-Derived T Cells.OncoTargets and therapy · 2021Article
- Patient-derived cancer modeling for precision medicine in colorectal cancer: beyond the cancer cell line.Cancer biology & therapy · 2020Review
- Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts.Journal for immunotherapy of cancer · 2019Article
- Evaluation of PD-1 blockade using a multicellular tumor spheroid model.American journal of translational research · 2019Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
<b/> Immunotherapy has transformed the therapeutic landscape of cancer, but the preclinical evaluation of combination approaches that will deepen and broaden its clinical benefit has lagged far behind due to the lack of expedient and easily accessible
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.