ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Basolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes.Communications biology · 2026Article
- Emotional information recruits specific neural dynamics to support hierarchical cognitive control.Social cognitive and affective neuroscience · 2026Article
- Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neuronal mismatch responses to auditory stimuli in the dorsal hippocampus of anesthetized rats.Communications biology · 2025Article
- Hippocampus shapes entorhinal cortical output through a direct feedback circuit.Nature neuroscience · 2025Article
- Amygdala stimulation transforms short-term memory into remote memory by persistent activation of atypical protein kinase C in the anterior cingulate cortex.Neuroscience · 2025Article
- Major individual and regional variations in unit entrainment by oscillations of different frequencies.Scientific reports · 2025Article
- Basolateral amygdala inputs to the nucleus accumbens shell modulate the consolidation of cued-response and inhibitory avoidance learning.Neurobiology of learning and memory · 2024Article
- Theoretical Considerations for Optimizing the Use of Optogenetics with Complex Behavior.Current protocols · 2023Article
- The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms.Neurobiology of stress · 2023Review
- Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation.Molecular neurodegeneration · 2023Article
- Immunization with a heat-killed preparation of Mycobacterium vaccae NCTC 11659 enhances auditory-cued fear extinction in a stress-dependent manner.Brain, behavior, and immunity · 2023Article
- Footshock-induced activation of the claustrum-entorhinal cortical pathway in freely moving mice.Physiological research · 2022Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Noradrenergic consolidation of social recognition memory is mediated by β-arrestin-biased signaling in the mouse prefrontal cortex.Communications biology · 2022Article
- The Sedentary Lifestyle and Masticatory Dysfunction: Time to Review the Contribution to Age-Associated Cognitive Decline and Astrocyte Morphotypes in the Dentate Gyrus.International journal of molecular sciences · 2022Review
- Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation.Nature communications · 2022Article
- The effect of stress and reward on encoding future fear memories.Behavioural brain research · 2022Review
- CPP impairs contextual learning at concentrations below those that block pyramidal neuron NMDARs and LTP in the CA1 region of the hippocampus.Neuropharmacology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Although evidence suggests that the basolateral amygdala (BLA) and dorsal hippocampus (DH) work together to influence the consolidation of spatial/contextual learning, the circuit mechanism by which the BLA selectively modulates spatial/contextual memory consolidation is not clear. The medial entorhinal cortex (mEC) is a critical region in the hippocampus-based system for processing spatial information. As an efferent target of the BLA, the mEC is a candidate by which the BLA influences the consolidation of such learning. To address several questions regarding this issue, male Sprague Dawley rats received optogenetic manipulations of different BLA afferents immediately after training in different learning tasks. Optogenetic stimulation of the BLA-mEC pathway using ChR2(E123A) after spatial and cued-response Barnes maze training enhanced and impaired retention, respectively, whereas optical inhibition of the pathway using eNpHR3.0 produced trends in the opposite direction. Similar stimulation of the BLA-posterior dorsal striatum pathway had no effect. BLA-mEC stimulation also selectively enhanced retention for the contextual, but not foot shock, component of a modified contextual fear-conditioning procedure. In both sets of experiments, only stimulation using bursts of 8 Hz light pulses significantly enhanced retention, suggesting the importance of driving activity in this frequency range. An 8 Hz stimulation of the BLA-mEC pathway increased local field potential power in the same frequency range in the mEC and in the DH. Together, the present findings suggest that the BLA modulates the consolidation of spatial/contextual memory via projections to the mEC and that activity within the 8 Hz range is critical for this modulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.