Evidence map›Paper›PMID 29431265›Full record

ArticleJournal of cellular and molecular medicine2018

Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells.

Hanho Shin, Ji Hye Han, Juhwan Yoon, Hyo Jung Sim, Tae Joo Park, Siyoung Yang, Eun Kyung Lee, Rohit N Kulkarni, Josephine M Egan, Wook Kim

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Hanho ShinDepartment of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Ji Hye HanDepartment of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Juhwan YoonDepartment of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Hyo Jung SimSchool of Life Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
Tae Joo ParkSchool of Life Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
Siyoung YangDepartment of Pharmacology, Ajou University School of Medicine, Suwon, South Korea.ORCID 0000-0002-6374-0140
Eun Kyung LeeDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Rohit N KulkarniDepartment of Islet Cell and Regenerative Biology, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.
Josephine M EganLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Wook KimDepartment of Molecular Science and Technology, Ajou University, Suwon, South Korea.ORCID 0000-0002-7701-4684
Ajou University · KRInstitute for Basic Science · KRCatholic University of Korea · KRJoslin Diabetes Center · USNational Institutes of Health · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
Drug Development of GLP-1 receptor agonistsZIAAG000905 · NIA · NATIONAL INSTITUTE ON AGING · PI EARLEY, JOSEPHINE · 2009 to 2019
$4.6M
NIDDK NIH HHS P30 DK036836
6 · The paper itself

Abstract

Cannabinoid 1 receptors (CB1Rs) are expressed in peripheral tissues, including islets of Langerhans, where their function(s) is under scrutiny. Using mouse β-cell lines, human islets and CB1R-null (CB1R

Indexed as

AnimalsAntigens, CDCyclic AMPDiabetes Mellitus, Type 2Gene Expression RegulationGlucokinaseGlucoseGlucose Transporter Type 2HumansInsulinInsulin-Secreting CellsMiceReceptor, Cannabinoid, CB1Receptor, InsulinAntigens, CDCNR1 protein, mouseCyclic AMPGlucokinaseGlucoseGlucose Transporter Type 2INSR protein, humanInsulinReceptor, Cannabinoid, CB1Receptor, Insulincannabinoid 1 receptorglucokinaseglucose transporter 2insulin secretionβ-cell function

Identifiers

PMID29431265
PMCPMC5867156
OpenAlexW2787927914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.