Observational studyJournal of the American Heart Association2018
Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients.
Observational study in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Trial
- Echocardiographic Features of Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction.Journal of the American College of Cardiology · 2019Trial
- Programmed cell death-related transcriptomic features are associated with aortic valve calcification progression: an integrated analysis of public datasets and clinical samples.Journal of thoracic disease · 2026Article
- Ten-year trajectory of Life's Essential 8 and aortic valve calcification.American journal of preventive cardiology · 2026Article
- Early Echocardiographic Changes Following Transcatheter Aortic Valve Implantation: A Comparative Analysis of Different Transcatheter Aortic Valve Systems.Journal of cardiovascular development and disease · 2026Article
- Prognostic performance of clinical scores and biomarkers in nonagenarians after TAVR requiring ICU admission.Scientific reports · 2026Article
- Alterations in Cardiac Structure and Function Associated With Sub-Severe Aortic Stenosis Progression: The ARIC Study.Journal of the American Heart Association · 2026Article
- Long-Term Outcomes in Aortic Stenosis: Mortality Analysis in a Selected Patient Group.Journal of personalized medicine · 2025Article
- Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis.European heart journal · 2025Article
- Association of lifestyle with valvular heart disease progression and life expectancy among elderly people from different socioeconomic backgrounds.BMC medicine · 2024Article
- Transcatheter aortic valve replacement before to breast cancer management: case report and literature review.European heart journal. Case reports · 2024Article
- Advanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters.Molecular medicine (Cambridge, Mass.) · 2024Article
- The value of Lp(a) and TG/HDLC in peripheral blood to assess the stability of carotid plaque in patients with ischemic stroke.Brain and behavior · 2024Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Stages of Valvular Heart Disease Among Older Adults in the Community: The Atherosclerosis Risk in Communities Study.Circulation · 2023Article
- Advanced cardiovascular multimodal imaging and aortic stenosis.Heart failure reviews · 2022Review
- Favorable Cardiovascular Health Is Associated With Lower Prevalence, Incidence, Extent, and Progression of Extracoronary Calcification: MESA.Circulation. Cardiovascular imaging · 2022Article
- Association between serum cystatin C level and hemodynamically significant aortic stenosis: a prospective cohort study.Journal of geriatric cardiology : JGC · 2021Article
- Safety and Operational Efficiency of Restructuring and Redeploying a Transcatheter Aortic Valve Replacement Service During the COVID-19 Pandemic: The Oxford Experience.Cardiovascular revascularization medicine : including molecular interventions · 2021Article
- Cumulative burden of clinically significant aortic stenosis in community-dwelling older adults.Heart (British Cardiac Society) · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe relationship between ideal cardiovascular health reflected in the cardiovascular health score (CVHS) and valvular heart disease is not known. The purpose of this study was to determine the association of CVHS attainment through midlife to late life with aortic stenosis prevalence and severity in late life. METHODS AND
resultsThe following 6 ideal cardiovascular health metrics were assessed in ARIC (Atherosclerosis Risk in Communities) Study participants at 5 examination visits between 1987 and 2013 (visits 1-4 in 1987-1998 and visit 5 in 2011-2013): smoking, body mass index, total cholesterol, blood pressure, physical activity, and blood glucose. Percentage attained CVHS was calculated in 6034 participants as the sum of CVHS at each visit/the maximum possible score. Aortic stenosis was assessed by echocardiography at visit 5 on the basis of the peak aortic valve velocity. Aortic stenosis was categorized sclerosis, mild stenosis, and moderate-to-severe stenosis. Mean age was 76±5 years, 42% were men, and 22% were black. Mean percentage attained CVHS was 63±14%, and the prevalence of aortic stenosis stages were 15.9% for sclerosis, 4.3% for mild stenosis, and 0.7% for moderate-to-severe stenosis. Worse percentage attained CVHS was associated with higher prevalence of aortic sclerosis (
conclusionsGreater attainment of ideal cardiovascular health in midlife to late life is associated with a lower prevalence of aortic sclerosis and stenosis in late life in a large cohort of older adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.