ArticleJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2018
Bayesian estimation of ELISA and gamma interferon test accuracy for the detection of bovine tuberculosis in caudal fold test-negative dairy cattle in Kuwait.
Article in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 9 citations in OpenAlex.
- Evaluation of the performance of the IFN-γ release assay in bovine tuberculosis free herds from five European countries.Veterinary research · 2023Article
- Risk factors associated with testing positive for tuberculosis in high-yielding Holstein cows.Tropical animal health and production · 2021Article
- Bayesian Assessment of the Accuracy of a PCR-Based Rapid Diagnostic Test for Bovine Tuberculosis in Swine.Frontiers in veterinary science · 2019Article
- Modeling the Accuracy of TwoFrontiers in veterinary science · 2019Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
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Abstract
Bovine tuberculosis (TB) is endemic in Kuwait; cattle identified as TB-positive using the caudal fold test (CFT) are culled. We used a Bayesian approach to estimate the sensitivity (Se) and specificity (Sp) of the IFNγ assay and ELISA, which are not routinely used in Kuwait in CFT-negative dairy cattle. Blood samples from CFT-negative cattle ( n = 384) collected from 38 dairy farms were tested by IFNγ assay and ELISA. The Se and Sp (95% CI) of the IFNγ were 85.0% (67.6-95.3%) and 90.4% (86.7-95.3%), respectively, whereas estimates for the ELISA were 61.1% (33.1-84.6%) and 85.4% (81.7-88.8%). TB prevalence (95 CI%) in CFT-negative cattle was estimated as 2.6% (0.5-9.5%). The IFNγ assay may play a role as an ancillary test for the identification of Mycobacterium bovis-infected cattle that are undetected by CFT.
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