Evidence map›Paper›PMID 29430995›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

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Maarten Ooms, Tetsuya Tsujikawa, Talakad G Lohith, Sanché N Mabins, Sami S Zoghbi, Akiko Sumitomo, Hanna Jaaro-Peled, Yasuyuki Kimura, Sanjay Telu, Victor W Pike and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Maarten Ooms1 Molecular Imaging Branch, NIMH, Bethesda, MD, USA.
Tetsuya Tsujikawa1 Molecular Imaging Branch, NIMH, Bethesda, MD, USA.
Talakad G Lohith1 Molecular Imaging Branch, NIMH, Bethesda, MD, USA.
Sanché N Mabins1 Molecular Imaging Branch, NIMH, Bethesda, MD, USA.
Sami S Zoghbi1 Molecular Imaging Branch, NIMH, Bethesda, MD, USA.
Akiko Sumitomo2 Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hanna Jaaro-Peled3 Department of Psychiatry, Johns Hopkins University School of Medicine, MD, USA.
Yasuyuki Kimura1 Molecular Imaging Branch, NIMH, Bethesda, MD, USA.ORCID 0000-0002-7927-9483
Sanjay Telu1 Molecular Imaging Branch, NIMH, Bethesda, MD, USA.
Victor W Pike1 Molecular Imaging Branch, NIMH, Bethesda, MD, USA.
Toshifumi Tomoda2 Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Robert B Innis1 Molecular Imaging Branch, NIMH, Bethesda, MD, USA.
Akira Sawa3 Department of Psychiatry, Johns Hopkins University School of Medicine, MD, USA.
Masahiro Fujita1 Molecular Imaging Branch, NIMH, Bethesda, MD, USA.
National Institutes of Health · USJohns Hopkins University · USKyoto University · JP

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
WOUND MIGRATION FORCE MONITORINGP41RR001192 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHOI, BERNARD · 1985 to 2011
$14.2M
DISC1-dependent defects in neural fate, corticogenesis and cognition in psychosisR01MH105660 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ISHIZUKA, KOKO, SAWA, AKIRA · 2014 to 2018
$2.8M
Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795NCRR NIH HHS P41 RR001192NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH105660
6 · The paper itself

Abstract

Although still a matter of controversy, disrupted in schizophrenia protein 1 (DISC1) was suggested as a potential inhibitor of phosphodiesterase 4 (PDE4). We used

Indexed as

AnimalsCarbon RadioisotopesCerebral CortexCyclic AMP-Dependent Protein KinasesCyclic Nucleotide Phosphodiesterases, Type 4Gene DeletionHaploinsufficiencyHeterozygoteHomozygoteMaleMiceMice, Inbred C57BLNerve Tissue ProteinsPhosphodiesterase 4 InhibitorsPositron-Emission TomographyRolipramCarbon RadioisotopesCyclic AMP-Dependent Protein KinasesCyclic Nucleotide Phosphodiesterases, Type 4Disc1 protein, mouseNerve Tissue ProteinsPhosphodiesterase 4 InhibitorsRolipram[C]()-Rolipramdisrupted in schizophrenialocus impairment mouse modelphosphodiesterase 4Positron emission tomography

Identifiers

PMID29430995
PMCPMC6668514
OpenAlexW2790636932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.