Evidence map›Paper›PMID 29430866›Full record

ArticleJournal of diabetes investigation2018

Difference in normal limit values of nerve conduction parameters between Westerners and Japanese people might need to be considered when diagnosing diabetic polyneuropathy using a Point-of-Care Sural Nerve Conduction Device (NC-stat®/DPNCheck™).

Kazuhiro Hirayasu, Hideyuki Sasaki, Shohei Kishimoto, Seigo Kurisu, Koji Noda, Kenichi Ogawa, Hiroto Tanaka, Yumiko Sakakibara, Shohei Matsuno, Hiroto Furuta and 3 more

Abstract readComparative Study
In one paragraph

Article in Journal of diabetes investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Screening for Diabetic Peripheral Neuropathy: Subjective Versus Objective Measures.The international journal of lower extremity wounds · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Lower Visceral Fat Area in Patients with Type 2 Diabetic Peripheral Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Challenges of neuropathic pain: focus on diabetic neuropathy.Journal of neural transmission (Vienna, Austria : 1996) · 2020
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kazuhiro HirayasuDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Hideyuki SasakiDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.ORCID http://orcid.org/0000-0001-5852-813X
Shohei KishimotoDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Seigo KurisuDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Koji NodaDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Kenichi OgawaDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Hiroto TanakaDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Yumiko SakakibaraDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Shohei MatsunoDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Hiroto FurutaDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Mikio AritaDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Keigo NakaDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.
Kishio NanjoDepartment of Medicine, Kihoku Hospital, Wakayama Medical University, Wakayama, Japan.

Funding

Japan Society for the Promotion of Science (JSPS) KAKENHI JP15K01723
6 · The paper itself

Abstract

AIM/

introductionStudies on a novel point-of-care device for nerve conduction study called DPNCheck have been limited to Westerners. We aimed to clarify Japanese normal limits of nerve action potential amplitude (Amp) and conduction velocity by DPNCheck (investigation I), and the validity of DPNCheck to identify diabetic symmetric sensorimotor polyneuropathy (DSPN; investigation II). MATERIALS AND

methodsFor investigation I, 463 non-neuropathic Japanese participants underwent DPNCheck examinations. Regression formulas calculating the normal limits of Amp and conduction velocity (Japanese regression formulas [JRF]) were determined by quantile regression and then compared with regression formulas of individuals from the USA (USRF). For investigation II, in 92 Japanese diabetes patients, 'probable DSPN' was diagnosed and nerve conduction abnormalities (NCA1: one or more abnormalities, and NCA2: two abnormalities in Amp and conduction velocity) were determined. Validity of NCAs to identify 'probable DSPN' was evaluated by determining sensitivity, specificity, reproducibility (kappa-coefficient) and the area under the curve of receiver operating characteristic curves.

resultsFor investigation I, JRF was different from USRF, and normal limits by JRF were higher than that of USRF. The prevalence of Amp abnormality calculated by JRF was significantly higher than that of USRF. For investigation II, the sensitivity, specificity and reproducibility of NCA1 and NCA2 judged from JRF were 85%, 86% and 0.57, and 43%, 100% and 0.56, respectively. These values of JRF were higher than those of USRF. The area under the curve of JRF (0.89) was larger than USRF (0.82).

conclusionsA significant difference in the normal limits of nerve conduction parameters by DPNCheck between Japanese and USA individuals was suggested. Validity to identify DSPN of NCAs might improve by changing the judgment criteria from USRF to JRF.

Indexed as

AdultAgedAsian PeopleDiabetic NeuropathiesFemaleHumansJapanMaleMiddle AgedNeural ConductionPoint-of-Care SystemsPolyneuropathiesReference ValuesSural NerveUnited StatesWhite PeopleClinicalComplication I - nerveDiagnosis and pathophysiology

Identifiers

PMID29430866
PMCPMC6123044

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.