Evidence map›Paper›PMID 29430834›Full record

ArticleThe FEBS journal2018

Nonenzymatic acetylation of ubiquitin Lys side chains is modulated by their neighboring residues.

Seo-Yeon Lee, Yun-Seok Choi, Eun-Hee Kim, Hae-Kap Cheong, Yun-Ju Lee, Jin-Gu Lee, Yihong Ye, Kyoung-Seok Ryu

Abstract read
In one paragraph

Article in The FEBS journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Small molecules that target the ubiquitin system.Biochemical Society transactions · 2020
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seo-Yeon LeeProtein Structure Group, Korea Basic Science Institute, Cheongju-Si, South Korea.
Yun-Seok ChoiProtein Structure Group, Korea Basic Science Institute, Cheongju-Si, South Korea.
Eun-Hee KimProtein Structure Group, Korea Basic Science Institute, Cheongju-Si, South Korea.
Hae-Kap CheongProtein Structure Group, Korea Basic Science Institute, Cheongju-Si, South Korea.
Yun-Ju LeeProtein Structure Group, Korea Basic Science Institute, Cheongju-Si, South Korea.
Jin-Gu LeeLaboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD, USA.
Yihong YeLaboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD, USA.
Kyoung-Seok RyuProtein Structure Group, Korea Basic Science Institute, Cheongju-Si, South Korea.

Funding

Roles of protein misfolding in neurodegenerative diseasesZIADK075145 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI YE, YIHONG · 2017 to 2025
$6.6M
Mechanism of polyubiquitin chain assembly by an ER-associated ubiquitin ligaseZ01DK036137 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI YE, YIHONG · 2007 to 2008
$591k
Intramural NIH HHS Z01 DK036137Intramural NIH HHS Z99 DK999999
6 · The paper itself

Abstract

Nonenzymatic acetylation of Lys side chains (Lys-SCs) by various in vivo reactive molecules has been suggested to play novel regulatory roles. Ubiquitin (UB) has seven Lys residues that are utilized for synthesis of specific poly-UB chains. To understand the nature of these Lys-SC modifications, the chemical acetylation rate and pK

Indexed as

AcetylationAmino Acid SequenceLysineMagnetic Resonance SpectroscopyModels, MolecularUbiquitinUbiquitinationLysineUbiquitin2-acetylthio acetamideNMRnonenzymatic acetylationubiquitinubiquitin Lys pKa

Identifiers

PMID29430834
PMCPMC5947880

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.