Evidence map›Paper›PMID 29430738›Full record

ArticleThe European journal of neuroscience2018

Neonatal adoptive transfer of lymphocytes rescues social behaviour during adolescence in immune-deficient mice.

Sarah M Clark, Chloe N Vaughn, Jennifer A Soroka, Xin Li, Leonardo H Tonelli

Abstract read
In one paragraph

Article in The European journal of neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The immune system on the TRAIL of Alzheimer's disease.Journal of neuroinflammation · 2020
    Review
  8. CD8Cytokine · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sarah M ClarkLaboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, 685 W. Baltimore Street, MSTF Building Room 934E, Baltimore, MD, 21201, USA.
Chloe N VaughnLaboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, 685 W. Baltimore Street, MSTF Building Room 934E, Baltimore, MD, 21201, USA.
Jennifer A SorokaLaboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, 685 W. Baltimore Street, MSTF Building Room 934E, Baltimore, MD, 21201, USA.
Xin LiLaboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, 685 W. Baltimore Street, MSTF Building Room 934E, Baltimore, MD, 21201, USA.
Leonardo H TonelliLaboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, 685 W. Baltimore Street, MSTF Building Room 934E, Baltimore, MD, 21201, USA.ORCID 0000-0002-9272-4959
University of Maryland, Baltimore · US

Funding

The Effects of Kynurenine Aminotransferase Inhibition in People with SchizophreniaP50MH103222 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHWARCZ, ROBERT · 2014 to 2023
$25.2M
NIMH NIH HHS P50 MH103222
6 · The paper itself

Abstract

Accumulating evidence has shown that lymphocytes modulate behaviour and cognition by direct interactions with the central nervous system. Studies have shown that reconstitution by adoptive transfer of lymphocytes from wild type into immune-deficient mice restores a number of neurobehavioural deficits observed in these models. Moreover, it has been shown that these effects are mostly mediated by T lymphocytes. Studies of adoptive transfer thus far have employed adult mice, but whether lymphocytes may also modulate behaviour during development remains unknown. In this study, neonate lymphocyte-deficient Rag2

Indexed as

Adoptive TransferAnimals, NewbornSocial BehaviorAgingAnimalsBehavior, AnimalDNA-Binding ProteinsExploratory BehaviorFood PreferencesGreen Fluorescent ProteinsImmunologic Deficiency SyndromesLymphocytesMaleMaze LearningMemoryMiceDNA-Binding ProteinsGreen Fluorescent ProteinsRag2 protein, mouseadoptive transfercognitiondevelopmentneuroimmuneT cells

Identifiers

PMID29430738
PMCPMC5902418
OpenAlexW2794371115

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.