ArticleClinical oral investigations2018
Radiotherapy alters the composition, structural and mechanical properties of root dentin in vitro.
Article in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Effectiveness of glass ionomer cements in the restorative treatment of radiation-related caries - a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Root caries lesions inhibition and repair using commercial high-fluoride toothpastes with or without tri-calcium phosphate and conventional toothpastes containing or not 1.5% arginine CaCOClinical oral investigations · 2020Trial
- Impact of radiotherapy on the morphological and compositional structure of intra-radicular dentin.Brazilian dental journalTrial
- Endodontic Management Before, During and After Head and Neck Radiotherapy: Biological, Diagnostic and Clinical Considerations in Head and Neck Cancer Patients.International endodontic journal · 2026Review
- Influence of Radiotherapy Timing on Sealer-Dentin Adhesion: A Confocal Microscopy and Push-Out Bond Strength Study.The journal of adhesive dentistry · 2026Article
- Microstructural changes in irradiated teeth revealed by swept-source optical coherence tomography.Scientific reports · 2026Article
- Effect of radiotherapy on the biomechanical preparation of different instrumentation kinematics.Odontology · 2026Article
- Dose-Dependent Effects of Simulated Clinical Radiotherapy on the Structure and Properties of Root Dentine.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Clinically relevant radiation therapy doses and obturation techniques modulate the adhesive performance of a resin-based sealer: interfacial integrity and bond strength analyses.Clinical oral investigations · 2026Article
- Article
- Does radiotherapy compromise root canal sealer penetration? An in vitro confocal laser microscopy study.Clinical oral investigations · 2025Article
- Water Absorption and Solubility of Fluoride-Based Restorative Materials Exposed to Ionizing Radiation.Polymers · 2025Article
- Role of diode laser (810 nm) and/or fluoride varnish for the treatment of gamma-irradiated hypersensitive human dentin (An in vitro study).Scientific reports · 2025Article
- Effect of radiation on microhardness and ultramorphological changes in dentin - AnJournal of conservative dentistry and endodontics · 2025Article
- Effect of radiation therapy on the dentin bond strength of a universal adhesive.BMC oral health · 2025Article
- Impact of radiotherapy in chemical composition and mechanical properties of human cervical dentin: an in vitro study.Journal of applied oral science : revista FOB · 2025Article
- Article
- Comparison of TiF4, CPP-ACP, and NaF in preventing demineralization in irradiated bovine enamel and dentin in vitro.Journal of applied oral science : revista FOB · 2025Article
- Article
- Impact of gamma radiation on marginal adaptation of nanohybrid composite and composition of dental hard tissues - Scanning electron microscopy and X-ray diffraction analysis: AnJournal of conservative dentistry and endodontics · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectivesPost-radiation dental lesions affect mainly the cervical area of the tooth. Until now, there are quite few evidences regarding the effects of radiation exposure on root dentin breakdown. To better understand this effect, we used human root dentin specimens obtained from third molars from similarly aged individuals. MATERIALS AND
methodsTwenty specimens were analyzed by the surface hardness (SH), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD) to evaluate the baseline properties of their root dentin. Other six human teeth were prepared and analyzed by scanning electron microscopy (SEM). Then the specimens were randomly distributed between two groups (n = 13 per group) and irradiated with a total dose of 55 or 70 Gy in a linear accelerator. The percentage of EDX and surface hardness loss (%SHL) were determined based on measurements before and after irradiation. The specimens were also analyzed after irradiation by SEM and XRD. The Ca/P weight ratio was calculated.
resultsBased on SEM analysis, radiation exposure induced dehydration of the dentin. The Ca/P weight ratio decreased (p = 0.0045). The %SHL of specimens irradiated with 70 Gy was higher than that of the 55-Gy group (p < 0.05), although even the lower dose induced root dentin breakdown.
conclusionsOverall, we can state that radiation exposure changes the composition and structure of human root dentin, which detrimentally affect its hardness. CLINICAL RELEVANCE: The changes reported herein might influence the selection of the dental materials and will bring new knowledge in this field to prevent radiation-related caries in root dentin.
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