Evidence map›Paper›PMID 29430571›Full record

ArticleInternational journal of clinical biostatistics and biometrics2017

Bayesian Cox Proportional Hazards Model in Survival Analysis of HACE1 Gene with Age at Onset of Alzheimer's Disease.

Ke-Sheng Wang, Ying Liu, Shaoqing Gong, Chun Xu, Xin Xie, Liang Wang, Xingguang Luo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of clinical biostatistics and biometrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Ke-Sheng WangDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN, USA.
Ying LiuDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN, USA.
Shaoqing GongSchool of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, China.
Chun XuDepartment of Health and Biomedical Sciences, College of Health Affairs, University of Texas Rio Grande Valley, Brownsville, TX, USA.
Xin XieDepartment of Economics and Finance, College of Business and Technology, East Tennessee State University, Johnson City, TN, USA.
Liang WangDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN, USA.
Xingguang LuoBiological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.
East Tennessee State University · US

Funding

Post-GWAS transcriptome-wide LncRNA expression profiling in alcohol dependenceR21AA023237 · NIAAA · YALE UNIVERSITY · PI LUO, XINGGUANG · 2015 to 2016
$344k
Deep sequencing of genes in ethanol-metabolism pathway in alcoholismR21AA021380 · NIAAA · YALE UNIVERSITY · PI LUO, XINGGUANG · 2014 to 2015
$339k
NIAAA NIH HHS R21 AA021380NIAAA NIH HHS R21 AA023237
6 · The paper itself

Abstract

Alzheimer's disease (AD), the most common form of dementia, is a chronic neurodegenerative disease. The HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) gene is expressed in human brain and may play a role in the pathogenesis of neurodegenerative disorders. Till now, no previous study has reported the association of the HACE1 gene with the risk and age at onset (AAO) of AD; while few studies have checked the proportional hazards assumption in the survival analysis of AAO of AD using Cox proportional hazards model. In this study, we examined the associations of 14 single nucleotide polymorphisms (SNPs) in the HACE1 gene with the risk and the AAO of AD using 791 AD patients and 782 controls. Multiple logistic regression model identified one SNP (rs9499937 with p = 1.8×10

Indexed as

Age at onsetAlzheimer’s diseaseBayesian analysisCox modelHACE1Single nucleotide polymorphismsSurvival analysis

Identifiers

PMID29430571
PMCPMC5806706
OpenAlexW2781572283

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.