ArticlePain reports2018
The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K
Article in Pain reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Article
- Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability.bioRxiv : the preprint server for biology · 2025Article
- The Multi-targeted Effect of Fascaplysin on the Proliferation and Dedifferentiation of Schwann Cells Inhibits Peripheral Nerve Degeneration by Blocking CDK4/6 and Androgen Receptor.Experimental neurobiology · 2024Article
- Meningeal brain borders and migraine headache genesis.Trends in neurosciences · 2024Review
- Novel insight into atogepant mechanisms of action in migraine prevention.Brain : a journal of neurology · 2024Article
- Unraveling the interplay of neuroinflammatory signaling between parenchymal and meningeal cells in migraine headache.The journal of headache and pain · 2024Review
- Meningeal P2X7 Signaling Mediates Migraine-Related Intracranial Mechanical Hypersensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Meningeal Mechanisms and the Migraine Connection.Annual review of neuroscience · 2023Review
- Meningeal P2X7 signaling mediates migraine-related intracranial mechanical hypersensitivity.bioRxiv : the preprint server for biology · 2023Article
- Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain.The journal of headache and pain · 2023Article
- Atogepant - an orally-administered CGRP antagonist - attenuates activation of meningeal nociceptors by CSD.Cephalalgia : an international journal of headache · 2022Article
- Parenchymal neuroinflammatory signaling and dural neurogenic inflammation in migraine.The journal of headache and pain · 2021Review
- Combined onabotulinumtoxinA/atogepant treatment blocks activation/sensitization of high-threshold and wide-dynamic range neurons.Cephalalgia : an international journal of headache · 2021Article
- Activation of Peripheral and Central Trigeminovascular Neurons by Seizure: Implications for Ictal and Postictal Headache.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats.Cephalalgia : an international journal of headache · 2019Article
- New discoveries in migraine mechanisms and therapeutic targets.Current opinion in physiology · 2019Article
- Cranial Osteopathy: Obscurantism and Enlightenment.Cureus · 2019Review
- Spreading depression as a preclinical model of migraine.The journal of headache and pain · 2019Review
- Neuroimaging clues of migraine aura.The journal of headache and pain · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionCortical spreading depression (CSD) is believed to promote migraine headache by enhancing the activity and mechanosensitivity of trigeminal intracranial meningeal afferents. One putative mechanism underlying this afferent response involves an acute excitation of meningeal afferents by cortical efflux of K
objectivesWe sought to investigate whether (1) a brief meningeal K
methodsExtracellular single-unit recording were used to record the activity of meningeal afferents in anesthetized male rats. Stimulations included a brief meningeal application of K
resultsMeningeal K
conclusionWhile CGRP-mediated activation of meningeal afferents evoked by cortical efflux of K
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.