Evidence map›Paper›PMID 29430519›Full record

ArticleeNeuro

Heterogeneities in Axonal Structure and Transporter Distribution Lower Dopamine Reuptake Efficiency.

Cihan Kaya, Mary H Cheng, Ethan R Block, Tom M Bartol, Terrence J Sejnowski, Alexander Sorkin, James R Faeder, Ivet Bahar

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Cihan KayaDepartment of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0003-2524-8072
Mary H ChengDepartment of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0001-5833-8221
Ethan R BlockDepartment of Science, Chatham University, Pittsburgh, PA 15232.
Tom M BartolComputational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
Terrence J SejnowskiComputational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.ORCID 0000-0002-0622-7391
Alexander SorkinDepartment of Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
James R FaederDepartment of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Ivet BaharDepartment of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
University of Pittsburgh · USSalk Institute for Biological Studies · USChatham University · US

Funding

TrainingP41GM103712 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COMPEAU, PHILLIP EDWARD CHARLES · 2012 to 2021
$16.3M
Regulation of Dopamine Transporter by TraffickingR01DA014204 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALEXANDER D SORKIN · 2001 to 2026
$8.3M
NIDA Center of Excellence OF Computational Drug Abuse Research (CDAR)P30DA035778 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAHAR, IVET, XIE, XIANG-QUN · 2014 to 2018
$5.4M
NIDA NIH HHS R01 DA014204NIGMS NIH HHS P41 GM103712
6 · The paper itself

Abstract

Efficient clearance of dopamine (DA) from the synapse is key to regulating dopaminergic signaling. This role is fulfilled by DA transporters (DATs). Recent advances in the structural characterization of DAT from

Indexed as

Action PotentialsAnimalsAxonsBrainDopamineDopamine Plasma Membrane Transport ProteinsDopaminergic NeuronsHumansMice, TransgenicMolecular Dynamics SimulationProtein ConformationSynaptic TransmissionTissue Culture TechniquesDopamineDopamine Plasma Membrane Transport ProteinsDopamine reuptakedopamine transporterspatial simulationstochastics

Identifiers

PMID29430519
PMCPMC5804147
OpenAlexW2788822652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.