Evidence map›Paper›PMID 29430518›Full record

ArticlePolicy insights from the behavioral and brain sciences2017

Alcohol Misuse Across the Lifespan: Insights from Developmental Studies in Behavior Genetics.

Jeanne E Savage, Elizabeth C Long, Sally I-Chun Kuo, Megan E Cooke, Jinni Su, Peter B Barr, Jessica E Salvatore

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Policy insights from the behavioral and brain sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Classification of Alcohol Use Disorder With Explainable AI.Alcohol, clinical & experimental research · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeanne E SavageVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Elizabeth C LongVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Sally I-Chun KuoDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Megan E CookeVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Jinni SuDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Peter B BarrDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Jessica E SalvatoreVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.

Funding

Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIELLE M DICK · 2014 to 2026
$19.6M
Genetics, Romantic Relationships, and Alcohol Misuse in Emerging AdulthoodK01AA024152 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2016 to 2020
$741k
Integrating Genetics, Brain Imaging and Phenotypic Subtypes in Binge DrinkersF31AA024380 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI COOKE, MEGAN · 2015 to 2016
$67k
Drinking Motives in Internalizing and Externalizing Pathways to Alcohol MisuseF31AA024378 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAVAGE, JEANNE ELIZABETH · 2016 to 2016
$42k
NIAAA NIH HHS F31 AA024378NIAAA NIH HHS F31 AA024380NIAAA NIH HHS K01 AA024152NIAAA NIH HHS P50 AA022537
6 · The paper itself

Abstract

Alcohol misuse, one of today's greatest public health challenges, is a developmentally dynamic, complex behavior at the intersection of genetic and environmental influences. This review examines such influences from a behavior genetics perspective and discusses implications for public policy. Alcohol misuse is moderately heritable with genetic influences accounting for around 50% of its variance, but to date few specific genes have been identified. However, numerous environmental and social factors moderate genetic risk, including parents, peers, romantic partners, family dynamics, employment, laws, and cultural influences. These moderating factors change in salience across development, and, accordingly, no one-size-fits-all approach is suitable for reducing alcohol misuse at a large scale. We provide examples of some effective prevention and intervention programs and discuss a framework for using the behavior genetics evidence to inform future public policy efforts.

Indexed as

alcohol misusealcohol use disorderbehavior geneticsdevelopmentpublic policy

Identifiers

PMID29430518
PMCPMC5802413

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.