Evidence map›Paper›PMID 29430384›Full record

ArticleCurrent addiction reports2017

Exercise as a Prevention for Substance Use Disorder: A Review of Sex Differences and Neurobiological Mechanisms.

Wendy J Lynch, Andrea M Robinson, Jean Abel, Mark A Smith

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current addiction reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Wendy J LynchAssociate Professor of Psychiatry and Neurobehavioral Sciences, University of Virginia: P.O. Box 801402, Charlottesville, VA 22904, 434-243-0580 (phone); 434-973-7031 (fax).
Andrea M RobinsonPostdoctoral Fellow of Psychology, Davidson College: Box 7136 Davidson, NC 28035, 704-894-3012 (phone); 704-894-2512 (fax).
Jean AbelAssistant Professor of Psychiatry and Neurobehavioral Sciences, University of Virginia; P.O. Box 801402, Charlottesville, VA 22904-1402, 434) 243-5767 (phone); 434-973-7031 (fax).
Mark A SmithProfessor of Psychology, Davidson College, Davidson, NC 28035, 704-894-2470 (phone); 704-894-2512 (fax).
Davidson College · USUniversity of Virginia · US

Funding

Dopaminergic and Glutamatergic Mechanisms of Cocaine Addiction: Sex DifferencesR01DA024716 · NIDA · UNIVERSITY OF VIRGINIA · PI Wendy Jean Lynch · 2008 to 2026
$6.1M
Social Influences on Drug-Seeking BehaviorR01DA031725 · NIDA · DAVIDSON COLLEGE · PI SMITH, MARK A · 2012 to 2022
$3.1M
Exercise as a Sex-Specific Intervention Strategy for Cocaine AddictionR01DA039093 · NIDA · UNIVERSITY OF VIRGINIA · PI LYNCH, WENDY JEAN · 2015 to 2019
$1.7M
Physical Activity and Substance AbuseR01DA027485 · NIDA · DAVIDSON COLLEGE · PI SMITH, MARK A · 2009 to 2013
$943k
NIDA NIH HHS R01 DA024716NIDA NIH HHS R01 DA027485NIDA NIH HHS R01 DA031725NIDA NIH HHS R01 DA039093
6 · The paper itself

Abstract

purpose of reviewThis report provides an update on clinical and preclinical findings for the efficacy of exercise to prevent substance use disorder with a focus on recent evidence for sex differences and neurobiological mechanisms. RECENT

findingsExercise/physical activity is associated with decreased drug use in humans. Preclinical results further indicate that exercise decreases vulnerability to drug use and the development of features of substance use disorder, and suggest that females have an enhanced sensitivity to its reward-substitution effects. However, certain exercise conditions may sensitize the reward pathway and enhance vulnerability suggesting that parallel observations in humans (e.g., increased prescription opioid misuse and heroin use in high-school athletes) may be biologically-based. SUMMARY: Exercise is a promising prevention strategy for substance use disorder. Further work is needed to establish its efficacy as a sex-specific strategy using larger samples, and to understand the exercise conditions that induce beneficial versus risk-enhancing effects.

Indexed as

acquisitionaddictionanimal modelsbiological mechanismsclinicaldrug use escalationdrug use initiationexercisegender differencesgonadal hormonesinterventionphysical activitypreclinicalpreventionsex differencessex-specificsubstance use disorder

Identifiers

PMID29430384
PMCPMC5802367
OpenAlexW2766182457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.