ArticleMolecular systems design & engineering2017
Modulating the Catalytic Activity of Enzyme-like Nanoparticles Through their Surface Functionalization.
Article in Molecular systems design & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Beyond antibiotics: engineered metal nanozymes for resistance-evading antibacterial therapy.Journal of nanobiotechnology · 2026Review
- Review
- pH-responsive nanozymes: multifunctional platforms for biomedical catalysis toward clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Photoactive nanocatalysts as DTT-assisted BSA-AuNCs with enhanced oxidase-mimicking ability for sensitive fluorometric detection of antioxidants.Journal of nanobiotechnology · 2024Article
- Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Increased Range of Catalytic Activities of Immobilized Compared to Colloidal Gold Nanoparticles.Molecules (Basel, Switzerland) · 2023Article
- Bioorthogonal nanozymes for breast cancer imaging and therapy.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Spotting Local Environments in Self-Assembled Monolayer-Protected Gold Nanoparticles.ACS nano · 2022Article
- Article
- Degradable ZnS-Supported Bioorthogonal Nanozymes with Enhanced Catalytic Activity for Intracellular Activation of Therapeutics.Journal of the American Chemical Society · 2022Article
- Novel Magnetic Polymeric Filters with Laccase-Based Nanoparticles for Improving Congo Red Decolorization in Bioreactors.Polymers · 2022Article
- Nanomaterial-based bioorthogonal nanozymes for biological applications.Chemical Society reviews · 2021Review
- Inside a Shell-Organometallic Catalysis Inside Encapsulin Nanoreactors.Angewandte Chemie (International ed. in English) · 2021Article
- In situ activation of therapeutics through bioorthogonal catalysis.Advanced drug delivery reviews · 2021Review
- Molecular Dynamics Simulations of a Catalytic Multivalent Peptide-Nanoparticle Complex.International journal of molecular sciences · 2021Article
- Intracellular Activation of Anticancer Therapeutics Using Polymeric Bioorthogonal Nanocatalysts.Advanced healthcare materials · 2021Article
- Development of coinage metal nanoclusters as antimicrobials to combat bacterial infections.Journal of materials chemistry. B · 2020Review
- Gold Nanozymes: From Concept to Biomedical Applications.Nano-micro letters · 2020Review
- Protection and Isolation of Bioorthogonal Metal Catalysts by Using Monolayer-Coated Nanozymes.Chembiochem : a European journal of chemical biology · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The inclusion of transition metal catalysts into nanoparticle scaffolds permits the creation of catalytic nanosystems (nanozymes) able to imitate the behaviour of natural enzymes. Here we report the fabrication of a family of nanozymes comprised of bioorthogonal ruthenium catalysts inserted in the protective monolayer of gold nanoparticles. By introducing simple modifications to the functional groups at the surface of the nanozymes, we have demonstrated control over the kinetic mechanism of our system. Cationic nanozymes with hydrophobic surface functionalities tend to replicate the classical Michaelis Menten model, while those with polar groups display substrate inhibition behaviour, a key mechanism present in 20 % of natural enzymes. The structural parameters described herein can be used for creating artificial nanosystems that mimic the complexity observed in cell machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.