Evidence map›Paper›PMID 29430286›Full record

ArticleOxidative medicine and cellular longevity2017

Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung.

Natalia El-Merhie, Eveline Baumgart-Vogt, Adrian Pilatz, Susanne Pfreimer, Bianca Pfeiffer, Oleg Pak, Djuro Kosanovic, Michael Seimetz, Ralph Theo Schermuly, Norbert Weissmann and 1 more

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Mitochondrial DNA variation modulates alveolar development in newborn mice exposed to hyperoxia.American journal of physiology. Lung cellular and molecular physiology · 2019
    Article
  11. CytochromeFrontiers in physiology · 2019
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Natalia El-MerhieInstitute for Anatomy and Cell Biology II, Division of Medical Cell Biology, Justus Liebig University, Giessen, Germany.
Eveline Baumgart-VogtInstitute for Anatomy and Cell Biology II, Division of Medical Cell Biology, Justus Liebig University, Giessen, Germany.ORCID 0000-0002-8265-3763
Adrian PilatzDepartment of Urology, Pediatric Urology and Andrology, Justus Liebig University, Giessen, Germany.
Susanne PfreimerInstitute for Anatomy and Cell Biology II, Division of Medical Cell Biology, Justus Liebig University, Giessen, Germany.
Bianca PfeifferInstitute for Anatomy and Cell Biology II, Division of Medical Cell Biology, Justus Liebig University, Giessen, Germany.
Oleg PakExcellence Cluster Cardio-Pulmonary System (ECCPS), German Lung Center (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Justus Liebig University, Giessen, Germany.
Djuro KosanovicExcellence Cluster Cardio-Pulmonary System (ECCPS), German Lung Center (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Justus Liebig University, Giessen, Germany.ORCID 0000-0002-7094-2269
Michael SeimetzExcellence Cluster Cardio-Pulmonary System (ECCPS), German Lung Center (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Justus Liebig University, Giessen, Germany.
Ralph Theo SchermulyExcellence Cluster Cardio-Pulmonary System (ECCPS), German Lung Center (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Justus Liebig University, Giessen, Germany.ORCID 0000-0002-5167-6970
Norbert WeissmannExcellence Cluster Cardio-Pulmonary System (ECCPS), German Lung Center (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Justus Liebig University, Giessen, Germany.
Srikanth KarnatiInstitute for Anatomy and Cell Biology II, Division of Medical Cell Biology, Justus Liebig University, Giessen, Germany.ORCID 0000-0001-9083-2916

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial biogenesis and adequate energy production in various organs of mammals are necessary for postnatal adaptation to extrauterine life in an environment with high oxygen content. Even though transgenic mice are frequently used as experimental models, to date, no combined detailed molecular and morphological analysis on the mitochondrial compartment in different lung cell types has been performed during postnatal mouse lung development. In our study, we revealed a significant upregulation of most mitochondrial respiratory complexes at protein and mRNA levels in the lungs of P15 and adult animals in comparison to newborns. The majority of adult animal samples showed the strongest increase, except for succinate dehydrogenase protein (SDHD). Likewise, an increase in mRNA expression for mtDNA transcription machinery genes (

Indexed as

AnimalsElectron TransportEmbryonic DevelopmentLungMiceMitochondria

Identifiers

PMID29430286
PMCPMC5753018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.