Evidence map›Paper›PMID 29430254›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2017

Anti-Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery.

Mysrayn Y F A Reis, Simone M Dos Santos, Danielle R Silva, Márcia V Silva, Maria Tereza S Correia, Daniela M A Ferraz Navarro, Geanne K N Santos, Fernando Hallwass, Otávio Bianchi, Alexandre G Silva and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Evidence-based complementary and alternative medicine : eCAM · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Mysrayn Y F A ReisPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual da Paraíba, Rua Juvêncio Arruda S/N, Bairro Universitário, 58429-600 Campina Grande, PB, Brazil.
Simone M Dos SantosPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
Danielle R SilvaPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
Márcia V SilvaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.ORCID 0000-0002-2221-5059
Maria Tereza S CorreiaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.ORCID 0000-0003-4920-9975
Daniela M A Ferraz NavarroDepartamento de Química Fundamental, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
Geanne K N SantosDepartamento de Química Fundamental, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
Fernando HallwassDepartamento de Química Fundamental, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
Otávio BianchiProgramas de Pós-Graduação em Engenharia e Ciência dos Materiais e Ciências da Saúde, Universidade de Caxias do Sul, Rua Francisco Getúlio Vargas, No. 1130, Petrópolis, 95070-560 Caxias do Sul, RS, Brazil.
Alexandre G SilvaDepartamento de Antibióticos, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
Janaína V MeloFaculdade Boa Viagem, DeVry, Av. Jean Emile Favre, No. 422, Imbiribeira, 61200-060 Recife, PE, Brazil.
Alessandra B MattosLaboratório de Microscopia e Microanálise, Centro de Tecnologias Estratégicas do Nordeste, Av. Prof. Luís Freire, No. 1, Cidade Universitária, 50740-540 Recife, PE, Brazil.ORCID 0000-0001-7512-9456
Rafael M XimenesDepartamento de Antibióticos, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.ORCID 0000-0002-2011-2865
Giovanna MachadoLaboratório de Microscopia e Microanálise, Centro de Tecnologias Estratégicas do Nordeste, Av. Prof. Luís Freire, No. 1, Cidade Universitária, 50740-540 Recife, PE, Brazil.
Karina L A SaraivaNúcleo de Plataformas Tecnológicas, Instituto Aggeu Magalhães, FIOCRUZ, Av. Prof. Moraes Rego S/N, Cidade Universitária, 50740-465 Recife, PE, Brazil.
Universidade Federal de Pernambuco · BRCentro de Tecnologias Estratégicas do Nordeste · BRFundação Oswaldo Cruz · BRUniversidade de Caxias do Sul · BRUniversidade Estadual da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil. Among these communities, babassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis. This study aimed to evaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery. Topical anti-inflammatory activity was evaluated in mice ear edema using PMA, arachidonic acid, ethyl phenylpropiolate, phenol, and capsaicin as phlogistic agents. A microemulsion system was successfully developed using a Span® 80/Kolliphor® EL ratio of 6 : 4 as the surfactant system (S), propylene glycol and water (3 : 1) as the aqueous phase (A), and babassu oil as the oil phase (O), and analyzed through conductivity, SAXS, DSC, TEM, and rheological assays. Babassu oil and lauric acid showed anti-inflammatory activity in mice ear edema, through inhibition of eicosanoid pathway and bioactive amines. The developed formulation (39% A, 12.2% O, and 48.8% S) was classified as a bicontinuous to o/w transition microemulsion that showed a Newtonian profile. The topical anti-inflammatory activity of microemulsified babassu oil was markedly increased. A new delivery system of babassu microemulsion droplet clusters was designed to enhance the therapeutic efficacy of vegetable oil.

Identifiers

PMID29430254
PMCPMC5753019
OpenAlexW2781047547

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.