ArticleDementia and geriatric cognitive disorders extra
Gustatory Dysfunction as an Early Symptom of Semantic Dementia.
Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The Association Between Neurocognitive Disorders and Gustatory Dysfunction: A Systematic Review and Meta-Analysis.Neuropsychology review · 2024Pooled it
- Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group.Communications medicine · 2025Review
- Deficits in taste-guided behaviors and central processing of taste in the transgenic TDP-43Neurobiology of disease · 2025Article
- Network changes associated with right anterior temporal lobe atrophy: insight into unique symptoms.Brain communications · 2025Article
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Genomic study of taste perception genes in African Americans reveals SNPs linked to Alzheimer's disease.Scientific reports · 2024Article
- Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer's Disease.The Journal of infectious diseases · 2024Review
- Genomic Study of Taste Perception Genes in African Americans Reveals SNPs Linked to Alzheimer's Disease.bioRxiv : the preprint server for biology · 2024Article
- Sensory and motor deficits as contributors to early cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Nutrition, Exercise, and Cognitive Rehabilitation for Dementia Prevention.Juntendo Iji zasshi = Juntendo medical journal · 2024Review
- Volumetric analysis of hippocampal subregions and subfields in left and right semantic dementia.Brain communications · 2024Article
- D2/D3 Receptor Agonism: Paving the Way for a New Therapeutic Target for Taste Disorders in Parkinson's Disease and Other Conditions?The international journal of neuropsychopharmacology · 2022Article
- Association between Sour Taste SNPNutrients · 2021Article
- Detection and recognition thresholds for five basic tastes in patients with mild cognitive impairment and Alzheimer's disease dementia.BMC neurology · 2020Article
- Selective Peripheral Taste Dysfunction in APP/PS1 Mutant Transgenic Mice.Journal of Alzheimer's disease : JAD · 2020Article
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Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the gustatory function in patients with semantic dementia (SD).
methodsDetection and recognition thresholds of the 4 basic tastes (sweet, salty, sour, and bitter), taste discrimination, and taste identification were evaluated in 18 patients with SD, 18 patients with Alzheimer disease (AD), and 22 healthy controls.
resultsTotal detection and recognition threshold values were significantly higher in the SD and AD groups than in the control group. Patients with early-stage SD (Clinical Dementia Rating Scale score 0.5) exhibited significantly higher detection and recognition thresholds relative to controls, while increases in recognition threshold were only noted in patients with AD. Patients with SD exhibited significantly higher thresholds for the detection of sweet and salty tastes and the recognition of salty, sour, and bitter tastes, while patients with AD exhibited significantly higher thresholds only for the recognition of salty and sour tastes. Taste discrimination was preserved, whereas taste identification was disturbed, in both the SD and AD groups.
conclusionsGustatory dysfunction at both the sensory and semantic levels may be among the early symptoms of SD. Although patients with SD had difficulty detecting sweet tastes, they more easily recognized these tastes than others, which may explain their strong preference for sweets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.