Evidence map›Paper›PMID 29430177›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2018

Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease.

David Hutchinson, Judith Müller, Joseph E McCarthy, Yurii K Gun'ko, Navin Kumar Verma, Xuezhi Bi, Luisana Di Cristo, Laura Kickham, Dania Movia, Adriele Prina-Mello and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020
    Pooled it
  2. Article
  3. Review
  4. MEG3 Regulates CSE-Induced Apoptosis by Regulating miR-421/DFFB Signal Axis.International journal of chronic obstructive pulmonary disease · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Cadmium lung adsorption, citrullination and an enhanced risk of COPD.European respiratory review : an official journal of the European Respiratory Society · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 5 countries.

David HutchinsonRoyal Cornwall Hospital NHS Trust, Treliske.
Judith MüllerUniversity of Basel, Basel, Switzerland.
Joseph E McCarthySchool of Chemistry.
Yurii K Gun'koSchool of Chemistry.
Navin Kumar VermaLee Kong Chian School of Medicine, Nanyang Technological University.
Xuezhi BiBioprocessing Technology Institute, ASTAR Graduate Academy, Singapore.
Luisana Di CristoDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Laura KickhamDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Dania MoviaDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Adriele Prina-MelloAdvanced Materials for BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
Yuri VolkovAdvanced Materials for BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
Trinity College Dublin · IEAdvanced Materials and BioEngineering Research · IEBioprocessing Technology Institute · SGITMO University · RUNanyang Technological University · SGUniversity of Basel · CHUniversity of Exeter · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The objective of the study was to determine whether the cadmium-derived materials induce intracellular protein citrullination. Methods: Human A549 lung epithelial cells were exposed to cadmium in soluble and nanoparticulate forms represented by cadmium chloride (CdCl Results: CdO, ufCB and its combination with CdCl Conclusion: Cadmium oxide nanoparticle exposure facilitated post-translational citrullination of proteins.

Indexed as

A549 CellsCadmium ChlorideCadmium CompoundsCitrullinationCitrullineEpithelial CellsHumansKeratinsLungMetal NanoparticlesOxidesProtein Processing, Post-TranslationalPulmonary Disease, Chronic ObstructiveRisk AssessmentSmokingCadmium ChlorideCadmium Compoundscadmium oxideCitrullineKeratinsOxidesautoimmunitycadmiumcitrullinationCOPDcytokeratinsnanoparticlesproteomics

Identifiers

PMID29430177
PMCPMC5797466
OpenAlexW2787051590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.