Evidence map›Paper›PMID 29429899›Full record

ArticleCell chemical biology2018

Engineered Glycocalyx Regulates Stem Cell Proliferation in Murine Crypt Organoids.

Sara H Rouhanifard, Aime Lopez Aguilar, Lu Meng, Kelley W Moremen, Peng Wu

Open access · bronzeAbstract read
In one paragraph

Article in Cell chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech.Chembiochem : a European journal of chemical biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Mechanism by Which MC Controls Harmful Algal Blooms Revealed by Cell Morphology ofInternational journal of environmental research and public health · 2021
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sara H RouhanifardDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Aime Lopez AguilarDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lu MengComplex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Kelley W MoremenComplex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Peng WuDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: pengwu@scripps.edu.
Scripps Research Institute · USUniversity of Georgia · USAlbert Einstein College of Medicine · US

Funding

TR&D3. Approaches to Proteoglycan Function at Biochemical and Cellular LevelsP41GM103390 · NIGMS · UNIVERSITY OF GEORGIA · PI MOREMEN, KELLEY W. · 2012 to 2019
$14.5M
Recombinant Production of Glycosylation Enzymes for Biochem/Structural StudiesP01GM107012 · NIGMS · UNIVERSITY OF GEORGIA · PI PRESTEGARD, JAMES H. · 2013 to 2017
$7.5M
Chemoenzymatic methods for the detection of cellsurface glycansR01GM113046 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI WU, PENG · 2015 to 2018
$1.9M
NIGMS NIH HHS P01 GM107012NIGMS NIH HHS P41 GM103390NIGMS NIH HHS R01 GM113046
6 · The paper itself

Abstract

At the base of the intestinal crypt, long-lived Lgr5

Indexed as

Cell ProliferationAmino SugarsAnimalsCell DifferentiationCells, CulturedGlycocalyxHumansMice, Inbred C57BLOrganoidsPaneth CellsReceptors, G-Protein-CoupledStem CellsAmino SugarsLgr5 protein, mouseN-acetyllactosamineReceptors, G-Protein-Coupledenteroidenzymatic glycan engineeringglycosylationintestinal stem cellLacNAcPaneth cells

Identifiers

PMID29429899
PMCPMC5910180
OpenAlexW2786254040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.