ArticleParkinsonism & related disorders2018
Daytime sleepiness in dementia with Lewy bodies is associated with neuronal depletion of the nucleus basalis of Meynert.
Article in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Sleep disturbances in Lewy body dementia: A systematic review.International journal of geriatric psychiatry · 2022Pooled it
- Clinical correlates of sleep profiles in dementia with Lewy bodies: a latent class approach.Alzheimer's research & therapy · 2026Article
- Sleep disorders and sleep behaviors as predictors of neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Excessive daytime sleepiness is independently associated with dehydration among older adults.BMC geriatrics · 2026Article
- Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Lateral septal inhibition of nucleus basalis through direct and indirect pathways in focal limbic seizures.bioRxiv : the preprint server for biology · 2025Article
- Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Alterations in sleep-activity cycles and clock gene expression across the synucleinopathy spectrum.Translational neurodegeneration · 2025Article
- Subregion-specific associations of the basal forebrain with sleep and cognition in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Sleep Deficits Inter-Link Lower Basal Forebrain-Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men.The international journal of neuropsychopharmacology · 2023Article
- Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson's Disease Dementia: A 36 Months Follow Up Study.Movement disorders clinical practice · 2022Article
- Translational approaches to influence sleep and arousal.Brain research bulletin · 2022Review
- Associations between nutritional factors and excessive daytime sleepiness in older patients with chronic kidney disease.Aging clinical and experimental research · 2022Article
- Clinical features of Lewy body dementia: insights into diagnosis and pathophysiology.Journal of neurology · 2020Article
- Excessive Daytime Sleepiness in Major Dementia Syndromes.American journal of Alzheimer's disease and other dementias · 2019Article
- Cholinergic modulation of spatial learning, memory and navigation.The European journal of neuroscience · 2018Review
- REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB).Behavioural neurology · 2018Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
introductionExcessive daytime sleepiness is a commonly reported clinical feature of dementia with Lewy bodies (DLB) that can occur early in the disease. Cholinergic depletion is known to be severe in DLB, even when dementia severity is mild. The nucleus basalis of Meynert serves as a primary source of cortical acetylcholine, and has a role in facilitating cortical activation and arousal. We sought to determine whether daytime sleepiness at the initial evaluation of patients with DLB was associated with neuronal loss in the nucleus basalis of Meynert.
methodsAutopsy-confirmed patients who met clinical criteria for probable DLB at their initial evaluation and who were administered the informant-completed Epworth Sleepiness Scale were included in the study (n = 40). Each patient had a dementia at baseline (80% with mild severity) and two or more features of parkinsonism, visual hallucinations, fluctuations, or probable REM sleep behavior disorder. Quantitative digital pathology of the nucleus basalis of Meynert was performed in the DLB group and in 20 non-DLB autopsy controls.
resultsDLB had greater neuronal depletion in the nucleus basalis of Meynert (p < 0.0001) than pathologic controls. Sleepiness was present in 58% of the DLB group and those with daytime sleepiness had significantly lower neuron counts in the nucleus basalis of Meynert than their non-sleepy counterparts (p = 0.001). Regression modeling revealed that sleepiness was a stronger predictor of neuronal loss in the nucleus basalis of Meynert than visual hallucinations, fluctuations or dementia severity (p = 0.003).
conclusionsExcessive daytime sleepiness in early DLB is indicative of a more profound loss of basal forebrain cholinergic integrity.
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