ArticleCurrent biology : CB2018
Hidden Complexity of Yeast Adaptation under Simple Evolutionary Conditions.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Evolutionary adaptation proceeds through a small number of phenotypic modules.Molecular biology and evolution · 2026Article
- Toward a Functional Genetics of Adaptation: Insights From Microbial Experimental Evolution.Genome biology and evolution · 2026Review
- Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution.Nature ecology & evolution · 2026Article
- Experimental Evolution of Yeast Reveals Trade-offs Between Early and Late Stationary Phase.bioRxiv : the preprint server for biology · 2026Article
- Genotype-fitness mapping of adaptive mutants reveals shifting low-dimensional structure across divergent environments.PLoS biology · 2026Article
- Phenotypic heterogeneity in lag reflects an evolutionarily stable bet-hedging strategy.bioRxiv : the preprint server for biology · 2025Article
- Frequency-dependent fitness effects are ubiquitous.bioRxiv : the preprint server for biology · 2025Article
- Dynamic coexistence driven by physiological transitions in microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Quantifying Competitive Fitness in Yeast with High-Throughput Fluorescence Microscopy Imaging.Current protocols · 2025Article
- A high-resolution two-step evolution experiment in yeast reveals a shift from pleiotropic to modular adaptation.PLoS biology · 2024Article
- Regulatory networks may evolve to favor adaptive foresight.PLoS biology · 2024Article
- Gain- and loss-of-function alleles within signaling pathways lead to phenotypic diversity among individuals.iScience · 2024Article
- Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs.eLife · 2024Article
- Environmental memory alters the fitness effects of adaptive mutations in fluctuating environments.Nature ecology & evolution · 2024Article
- Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs.bioRxiv : the preprint server for biology · 2024Article
- Bayesian inference of relative fitness on high-throughput pooled competition assays.PLoS computational biology · 2024Article
- Predicting bacterial interaction outcomes from monoculture growth and supernatant assays.ISME communications · 2024Article
- Convergent genetic adaptation ofFrontiers in molecular biosciences · 2024Article
- Article
- Strong environmental memory revealed by experimental evolution in static and fluctuating environments.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Few studies have "quantitatively" probed how adaptive mutations result in increased fitness. Even in simple microbial evolution experiments, with full knowledge of the underlying mutations and specific growth conditions, it is challenging to determine where within a growth-saturation cycle those fitness gains occur. A common implicit assumption is that most benefits derive from an increased exponential growth rate. Here, we instead show that, in batch serial transfer experiments, adaptive mutants' fitness gains can be dominated by benefits that are accrued in one growth cycle, but not realized until the next growth cycle. For thousands of evolved clones (most with only a single mutation), we systematically varied the lengths of fermentation, respiration, and stationary phases to assess how their fitness, as measured by barcode sequencing, depends on these phases of the growth-saturation-dilution cycles. These data revealed that, whereas all adaptive lineages gained similar and modest benefits from fermentation, most of the benefits for the highest fitness mutants came instead from the time spent in respiration. From monoculture and high-resolution pairwise fitness competition experiments for a dozen of these clones, we determined that the benefits "accrued" during respiration are only largely "realized" later as a shorter duration of lag phase in the following growth cycle. These results reveal hidden complexities of the adaptive process even under ostensibly simple evolutionary conditions, in which fitness gains can accrue during time spent in a growth phase with little cell division, and reveal that the memory of those gains can be realized in the subsequent growth cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.