Evidence map›Paper›PMID 29429422›Full record

ArticlePsychological medicine2018

The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.

Hsin-Fang Chung, Nirmala Pandeya, Annette J Dobson, Diana Kuh, Eric J Brunner, Sybil L Crawford, Nancy E Avis, Ellen B Gold, Ellen S Mitchell, Nancy F Woods and 6 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. FIGO best practice recommendations for the mental health of women at menopausal age.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Guideline
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Age at menarche and risk of vasomotor menopausal symptoms: a pooled analysis of six studies.BJOG : an international journal of obstetrics and gynaecology · 2021
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 4 countries.

Hsin-Fang ChungSchool of Public Health,The University of Queensland,Brisbane,Queensland,Australia.
Nirmala PandeyaSchool of Public Health,The University of Queensland,Brisbane,Queensland,Australia.
Annette J DobsonSchool of Public Health,The University of Queensland,Brisbane,Queensland,Australia.
Diana KuhMedical Research Council Unit for Lifelong Health and Ageing at University College London,London,UK.
Eric J BrunnerDepartment of Epidemiology and Public Health,University College London,London,UK.
Sybil L CrawfordDepartment of Medicine,University of Massachusetts Medical School,Worcester,MA,USA.
Nancy E AvisDepartment of Social Sciences and Health Policy,Wake Forest School of Medicine,Medical Center Blvd,Winston-Salem,NC,USA.
Ellen B GoldDepartment of Public Health Sciences,University of California,Davis,CA,USA.
Ellen S MitchellFamily and Child Nursing,School of Nursing,University of Washington,Seattle,WA,USA.
Nancy F WoodsBiobehavioral Nursing and Health Systems,School of Nursing,University of Washington,Seattle,WA,USA.
Joyce T BrombergerDepartments of Epidemiology and Psychiatry,University of Pittsburgh,Pittsburgh,PA,USA.
Rebecca C ThurstonDepartments of Epidemiology and Psychiatry,University of Pittsburgh,Pittsburgh,PA,USA.
Hadine JoffeConnors Center for Women's Health and Department of Psychiatry,Brigham and Women's Hospital and Dana Farber Cancer Institute/Harvard Medical School,Boston,MA,USA.
Toyoko YoshizawaDepartment of Women's Health Nursing,Tohoku University Graduate School of Medicine,Sendai,Japan.
Debra AndersonMenzies Health Institute Queensland, Griffith University,Gold Coast,Queensland,Australia.
Gita D MishraSchool of Public Health,The University of Queensland,Brisbane,Queensland,Australia.
University of Queensland · AUUniversity of Pittsburgh · USBrigham and Women's Hospital · USGriffith University · AUMedical Research Council · GBNeurobehavioral Systems · USTohoku University · JPUniversity College London · GBUniversity of California, Davis · USUniversity of Massachusetts Chan Medical School · USUniversity of Washington · USWake Forest University · US

Funding

WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
British Heart Foundation RG/16/11/32334Medical Research Council MC_UU_12019/1Medical Research Council MR/R024227/1NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NINR NIH HHS U01 NR004061
6 · The paper itself

Abstract

backgroundMany women experience both vasomotor menopausal symptoms (VMS) and depressed mood at midlife, but little is known regarding the prospective bi-directional relationships between VMS and depressed mood and the role of sleep difficulties in both directions.

methodsA pooled analysis was conducted using data from 21 312 women (median: 50 years, interquartile range 49-51) in eight studies from the InterLACE consortium. The degree of VMS, sleep difficulties, and depressed mood was self-reported and categorised as never, rarely, sometimes, and often (if reporting frequency) or never, mild, moderate, and severe (if reporting severity). Multivariable logistic regression models were used to examine the bi-directional associations adjusted for within-study correlation.

resultsAt baseline, the prevalence of VMS (40%, range 13-62%) and depressed mood (26%, 8-41%) varied substantially across studies, and a strong dose-dependent association between VMS and likelihood of depressed mood was found. Over 3 years of follow-up, women with often/severe VMS at baseline were more likely to have subsequent depressed mood compared with those without VMS (odds ratios (OR) 1.56, 1.27-1.92). Women with often/severe depressed mood at baseline were also more likely to have subsequent VMS than those without depressed mood (OR 1.89, 1.47-2.44). With further adjustment for the degree of sleep difficulties at baseline, the OR of having a subsequent depressed mood associated with often/severe VMS was attenuated and no longer significant (OR 1.13, 0.90-1.40). Conversely, often/severe depressed mood remained significantly associated with subsequent VMS (OR 1.80, 1.38-2.34).

conclusionsDifficulty in sleeping largely explained the relationship between VMS and subsequent depressed mood, but it had little impact on the relationship between depressed mood and subsequent VMS.

Indexed as

ComorbidityData Interpretation, StatisticalDepressionFemaleFollow-Up StudiesHot FlashesHumansMenopauseMiddle AgedPrevalenceSleep Wake DisordersSweatingVasomotor SystemDepressed moodhot flushesmenopausal transitionnight sweatssleep difficultiesvasomotor menopausal symptoms

Identifiers

PMID29429422
PMCPMC6087679
OpenAlexW2792088141

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.