ArticleParticle and fibre toxicology2018
Concentration-dependent systemic response after inhalation of nano-sized zinc oxide particles in human volunteers.
Article in Particle and fibre toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Welding Fumes, a Risk Factor for Lung Diseases.International journal of environmental research and public health · 2020Pooled it
- Current state of knowledge on the health effects of engineered nanomaterials in workers: a systematic review of human studies and epidemiological investigations.Scandinavian journal of work, environment & health · 2019Pooled it
- The potential adverse human health effects of metal-containing nanoparticles: a scoping review.Journal of occupational medicine and toxicology (London, England) · 2025Review
- Cardiovascular Toxicity of Metal-Based Nanoparticles.International journal of molecular sciences · 2025Review
- Occupationally Relevant Zinc- and Copper-Containing Metal Fumes Inhibit Human THP-1 Macrophage TNF and IL-6 Responses to Bacterial Stimuli.Global challenges (Hoboken, NJ) · 2025Article
- Intratracheal Instillation of Silver Nanoparticles to Rats Induces Mitochondrial Fission and Aortic Damage: Protective Effect of Sodium Selenite.International journal of nanomedicine · 2025Article
- Zinc fever in a painter and varnisher: a case report.Journal of medical case reports · 2024Article
- Zinc Toxicity: Understanding the Limits.Molecules (Basel, Switzerland) · 2024Review
- Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms.Particle and fibre toxicology · 2024Article
- A Systematic Genotoxicity Assessment of a Suite of Metal Oxide Nanoparticles Reveals Their DNA Damaging and Clastogenic Potential.Nanomaterials (Basel, Switzerland) · 2024Article
- Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al.Archives of toxicology · 2024Article
- Toxicity of Metal Oxide Nanoparticles: Looking through the Lens of Toxicogenomics.International journal of molecular sciences · 2023Article
- Immune response to zinc oxide inhalation in metal fume fever, and the possible role of IL-17f.Scientific reports · 2023Article
- Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?Archives of toxicology · 2023Article
- Acute phase response following pulmonary exposure to soluble and insoluble metal oxide nanomaterials in mice.Particle and fibre toxicology · 2023Article
- Cerium Oxide Enhances the Toxicity of Zinc Oxide Nanoparticles in Human Lung Epithelial Cell Cultures.Toxics · 2022Article
- The High-Throughput In Vitro CometChip Assay for the Analysis of Metal Oxide Nanomaterial Induced DNA Damage.Nanomaterials (Basel, Switzerland) · 2022Article
- Nanotechnology in Cosmetics and Cosmeceuticals-A Review of Latest Advancements.Gels (Basel, Switzerland) · 2022Review
- Long-Term Inhalation of Ultrafine Zinc Particles Deteriorated Cardiac and Cardiovascular Functions in Rats of Myocardial Infarction.Frontiers in physiology · 2022Article
- Cell-biological effects of zinc oxide spheres and rods from the nano- to the microscale at sub-toxic levels.Cell biology and toxicology · 2021Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInhalation of high concentrations of zinc oxide particles (ZnO) may cause metal fume fever. In an earlier human inhalation study, no effects were observed after exposure to ZnO concentrations of 0.5 mg/m
methodsSixteen healthy subjects were exposed to filtered air and ZnO particles (0.5, 1.0 and 2.0 mg/m
resultsConcentration-dependent increases in symptoms, body temperature, acute phase proteins and neutrophils in blood were detected after ZnO inhalation. Significant effects were detected with ZnO concentrations of 1.0 mg/m
conclusionA concentration-response relationship with nano-sized ZnO particles in a low concentration range was demonstrated. Systemic inflammatory effects of inhaled nano-sized ZnO particles were observed at concentrations well below the occpational exposure limit for ZnO in many countries. It is recommended to reassess the exposure limit for ZnO at workplaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.