Evidence map›Paper›PMID 29429372›Full record

SynthesisCartilage2019

Anti-Inflammatory Effects of Intra-Articular Hyaluronic Acid: A Systematic Review.

Roy Altman, Asheesh Bedi, Ajay Manjoo, Faizan Niazi, Peter Shaw, Philip Mease

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 3 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Roy Altman1 Division of Rheumatology and Immunology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Asheesh Bedi2 Chief of Sports Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA.
Ajay Manjoo3 Department of Orthopedics, McMaster University, Hamilton, Ontario, Canada.
Faizan Niazi4 Ferring Pharmaceuticals Inc., Parsippany, NJ, USA.
Peter Shaw4 Ferring Pharmaceuticals Inc., Parsippany, NJ, USA.
Philip Mease5 Swedish-Providence-St. Joseph's Health Systems, Seattle, WA, USA.
Ferring Pharmaceuticals (United States) · USMcMaster University · CASt. Joseph Health System · USUniversity of California, Los Angeles · USUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOsteoarthritis (OA) is one of the leading causes of disability in the adult population. Common nonoperative treatment options include nonsteroidal anti-inflammatory drugs (NSAIDs), intra-articular corticosteroids, and intra-articular injections of hyaluronic acid (HA). HA is found intrinsically within the knee joint providing viscoelastic properties to the synovial fluid. HA therapy provides anti-inflammatory relief through a number of different pathways, including the suppression of pro-inflammatory cytokines and chemokines.

methodsWe conducted a systematic review to summarize the published literature on the anti-inflammatory properties of hyaluronic acid in osteoarthritis. Included articles were categorized based on the primary anti-inflammatory responses described within them, by the immediate cell surface receptor protein assessed within the article, or based on the primary theme of the article. Key findings aimed to describe the macromolecules and inflammatory-mediated responses associated with the cell transmembrane receptors.

resultsForty-eight articles were included in this systematic review that focused on the general anti-inflammatory effects of HA in knee OA, mediated through receptor-binding relationships with cluster determinant 44 (CD44), toll-like receptor 2 (TLR-2) and 4 (TLR-4), intercellular adhesion molecule-1 (ICAM-1), and layilin (LAYN) cell surface receptors. Higher molecular weight HA (HMWHA) promotes anti-inflammatory responses, whereas short HA oligosaccharides produce inflammatory reactions.

conclusionsIntra-articular HA is a viable therapeutic option in treating knee OA and suppressing inflammatory responses. HMWHA is effective in suppressing the key macromolecules that elicit the inflammatory response by short HA oligosaccharides.

Indexed as

AdultAnti-Inflammatory Agents, Non-SteroidalFemaleHumansHyaluronan ReceptorsHyaluronic AcidInjections, Intra-ArticularIntercellular Adhesion Molecule-1Knee JointLectins, C-TypeMaleOsteoarthritis, KneeSynovial FluidToll-Like Receptor 2Toll-Like Receptor 4Treatment OutcomeAnti-Inflammatory Agents, Non-SteroidalCD44 protein, humanHyaluronan ReceptorsHyaluronic AcidIntercellular Adhesion Molecule-1LAYN protein, humanLectins, C-TypeTLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4Viscosupplementsanti-inflammatoryhyaluronic acidkneeosteoarthritis

Identifiers

PMID29429372
PMCPMC6376563
OpenAlexW2789240532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.