Evidence map›Paper›PMID 29429000›Full record

ArticleInflammopharmacology2018

Prunus cerasoides fruit extract ameliorates inflammatory stress by modulation of iNOS pathway and Th1/Th2 immune homeostasis in activated murine macrophages and lymphocytes.

Anamika Sharma, Robin Joshi, Shiv Kumar, Rohit Sharma, Rajneesh, Yogendra Padwad, Mahesh Gupta

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Antioxidants (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anamika SharmaPharmacology and Toxicology Lab, Food and Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P., India.
Robin JoshiBiotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P., India.
Shiv KumarPharmacology and Toxicology Lab, Food and Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P., India.
Rohit SharmaPharmacology and Toxicology Lab, Food and Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P., India.
RajneeshPharmacology and Toxicology Lab, Food and Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P., India.
Yogendra PadwadPharmacology and Toxicology Lab, Food and Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P., India. yogendra@ihbt.res.in.
Mahesh GuptaPharmacology and Toxicology Lab, Food and Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P., India. mgupta@ihbt.res.in.
Institute of Himalayan Bioresource Technology · INAcademy of Scientific and Innovative Research · IN

Funding

Council of Scientific and Industrial Research CSC0130
6 · The paper itself

Abstract

The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a strong inhibition in production of nitric oxide (NO), reactive oxygen species (ROS), inflammatory cytokines (TNF-α/IL-6/IL-1β), inducible nitric oxide synthase (iNOS), and NF-kB in macrophages treated with PCFE. Splenic lymphocytes treated with PCFE also showed a reduction in Con-A-induced cell proliferation and numbers of CD3

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCytokinesFruitInflammationInterferon-gammaLipopolysaccharidesLymphocyte ActivationLymphocytesMacrophage ActivationMacrophagesMiceMice, Inbred C57BLNitric OxideNitric Oxide Synthase Type IIPhenolsAnti-Inflammatory Agents, Non-SteroidalCytokinesInterferon-gammaLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IINos2 protein, mousePhenolsPlant ExtractsReactive Oxygen SpeciesInflammatory cytokineLymphocytesMacrophagesNF-kB expressionPhenolicsPrunus cerasoides

Identifiers

PMID29429000
OpenAlexW2793045501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.