ArticleNeurosurgical review2018
Bone flap salvage in acute surgical site infection after craniotomy for tumor resection.
Article in Neurosurgical review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Bone flap preservation versus removal with immediate mesh cranioplasty for post-craniotomy infections: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Preoperative antibiotic prophylaxis regimen in brain tumour surgery in Sweden: a quasi-experimental study.Acta neurochirurgica · 2020Trial
- The role of bone flap explantation in the recurrence of surgical site infection after elective craniotomy: A multicenter propensity-matched cohort study.Neurosurgical review · 2026Article
- Autologous bone flap salvage strategies in postcraniotomy surgical site infections: A scoping review.Surgical neurology international · 2026Review
- [Application of iceberg theory in the diagnosis and treatment of refractory wounds at the surgical site after craniotomy].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Article
- Cross-sectional study on surgical site infections and adherence to intraoperative sterile protocols.Bioinformation · 2025Article
- Post-craniotomy infections: A point-by-point approach.Brain & spine · 2025Article
- Treatment of wound infections linked to neurosurgical implants.International wound journal · 2024Article
- Relationship between characteristics of glioma treatment and surgical site infections.Acta neurochirurgica · 2023Article
- Transcriptional Profiling of Phagocytic Leukocytes and Microglia Reveals a Critical Role for Reactive Oxygen Species in Biofilm Containment during Staphylococcus aureus Craniotomy Infection.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Early versus delayed debridement for surgical site infection after oncological neurosurgery.Surgical neurology international · 2022Article
- Timing of cranial reconstruction after cranioplasty infections: are we ready for a re-thinking? A comparative analysis of delayed versus immediate cranioplasty after debridement in a series of 48 patients.Neurosurgical review · 2021Article
- Transcriptional Diversity and Niche-Specific Distribution of Leukocyte Populations duringJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Bone flap management strategies for postcraniotomy surgical site infection.Surgical neurology international · 2021Article
- Immunopathogenesis of Craniotomy Infection and Niche-Specific Immune Responses to Biofilm.Frontiers in immunology · 2021Review
- TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection.Journal of neuroinflammation · 2020Article
- 3D Bioprinted Scaffolds Containing Viable Macrophages and Antibiotics Promote Clearance of Staphylococcus aureus Craniotomy-Associated Biofilm Infection.ACS applied materials & interfaces · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Craniotomy surgical site infections are an inherent risk and dreaded complication for the elective brain tumor patient. Sequelae can include delays in resumption in adjuvant treatments for multiple surgeries if staged cranioplasty is pursued. Here, the authors review their experience in operative debridement of surgical site infections with single-stage reimplantation of the salvaged craniotomy bone flap. A prospectively maintained database of a single surgeon's neuro-oncology patients from 2009 to 2017 (JRF) was queried to identify 11 patients with surgical site infection after craniotomy for tumor resection. All patients underwent a protocol of aggressive operative debridement including drilling the bone edges and intraoperative flap sterilization with single-stage reimplantation, followed by tailored-antibiotic therapy. Ten of the 11 patients with frankly contaminated bone flaps from surgical site infection were able to be salvaged in a single-stage procedure. Five of these patients underwent adjuvant chemotherapy and/or radiation without secondary complication. There was one treatment failure in a delayed fashion which required additional surgery for craniectomy; however, this occurred after adjuvant treatment was administered. Surgical debridement and bone flap salvage is safe and cost-effective in managing acute surgical site infections after craniotomy for tumors. Additionally, this practice is likely beneficial in expediting the resumption of cancer therapy.
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Registered trials
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