Evidence map›Paper›PMID 29428769›Full record

ArticleNeuropsychologia2018

Impaired spatial pattern separation performance in temporal lobe epilepsy is associated with visuospatial memory deficits and hippocampal volume loss.

Anny Reyes, Heather M Holden, Yu-Hsuan A Chang, Vedang S Uttarwar, David P Sheppard, Nicole E DeFord, Shannon Yandall DeJesus, Leena Kansal, Paul E Gilbert, Carrie R McDonald

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Restoration of sFRP3 Preserves the Neural Stem Cell Pool and Spatial Discrimination Ability in a Mouse Model of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  7. Article
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  9. Article
  10. Review
  11. Article
  12. Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  13. Mechanism of seizure-induced retrograde amnesia.Progress in neurobiology · 2021
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Anny ReyesSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Heather M HoldenSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Yu-Hsuan A ChangCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Vedang S UttarwarCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
David P SheppardDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Nicole E DeFordDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Shannon Yandall DeJesusDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Leena KansalDepartment of Neurosciences, University of California, San Diego, CA, USA.
Paul E GilbertDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Carrie R McDonaldCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, CA, USA. Electronic address: camcdonald@ucsd.edu.
San Diego State University · USUniversity of California, San Diego · US

Funding

THE INTERSECTION OF LANGUAGE AND AFFECTR25GM058906 · NIGMS · SAN DIEGO STATE UNIVERSITY · PI TONG, WILLIAM G. · 1999 to 2021
$10.7M
Multimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4M
Mnemonic Processing Deficits in Older Adults at Risk for Alzheimer's DiseaseR01AG034202 · NIA · SAN DIEGO STATE UNIVERSITY · PI GILBERT, PAUL E · 2011 to 2015
$1.1M
NIA NIH HHS R01 AG034202NIGMS NIH HHS R25 GM058906NINDS NIH HHS R01 NS065838
6 · The paper itself

Abstract

Individuals with chronic temporal lobe epilepsy (TLE) experience episodic memory deficits that may be progressive in nature. These memory decrements have been shown to increase with the extent of hippocampal damage, a hallmark feature of TLE. Pattern separation, a neural computational mechanism thought to play a role in episodic memory formation, has been shown to be negatively affected by aging and in individuals with known hippocampal dysfunction. Despite the link between poor pattern separation performance and episodic memory deficits, behavioral pattern separation has not been examined in patients with TLE. We examined pattern separation performance in a group of 22 patients with medically-refractory TLE and 20 healthy adults, using a task hypothesized to measure spatial pattern separation with graded levels of spatial interference. We found that individuals with TLE showed less efficient spatial pattern separation performance relative to healthy adults. Poorer spatial pattern separation performance in TLE was associated with poorer visuospatial memory, but only under high interference conditions. In addition, left hippocampal atrophy was associated with poor performance in the high interference condition in TLE. These data suggest that episodic memory impairments in patients with chronic, refractory TLE may be partially due to less efficient pattern separation, which likely reflects their underlying hippocampal dysfunction.

Indexed as

Pattern Recognition, VisualSpace PerceptionAdultAtrophyDiscrimination, PsychologicalDrug Resistant EpilepsyEpilepsy, Temporal LobeFemaleHippocampusHumansMagnetic Resonance ImagingMaleMemory DisordersMemory, EpisodicMiddle AgedOrgan SizeEpisodic memoryHippocampal dysfunctionMedial temporal lobeProgressive memory declineSpatial memory

Identifiers

PMID29428769
PMCPMC5873595
OpenAlexW2793490209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.