Evidence map›Paper›PMID 29428697›Full record

ArticleOral surgery, oral medicine, oral pathology and oral radiology2018

Transient bacteremia induced by dental cleaning is not associated with infection of central venous catheters in patients with cancer.

Saad Usmani, Linda Choquette, Robert Bona, Richard Feinn, Zainab Shahid, Rajesh V Lalla

Registry-linked trialAbstract read
In one paragraph

Article in Oral surgery, oral medicine, oral pathology and oral radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00798330 (Pilot Study on Transient Bacteremia and Blood Stream Infections After Invasive Dental Procedures in Cancer Patients With Central Venous Catheters), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00798330 completednot on this map

Pilot Study on Transient Bacteremia and Blood Stream Infections After Invasive Dental Procedures in Cancer Patients With Central Venous Catheters

TypeobservationalSponsorRajesh LallaRan2012 to 2012Enrolled27ConditionsCancer
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Saad UsmaniDepartment of Hematologic Oncology and Blood Disorders, Levine Cancer Institute/Carolinas Healthcare System, Charlotte, NC, USA.
Linda ChoquetteThe Jackson Laboratory, Farmington, CT, USA.
Robert BonaDepartment of Medical Sciences, Frank H. Netter School of Medicine, Quinnipiac University, Hamden, CT, USA.
Richard FeinnDepartment of Medical Sciences, Frank H. Netter School of Medicine, Quinnipiac University, Hamden, CT, USA.
Zainab ShahidDivision of Infectious Diseases, Carolinas Healthcare System, Charlotte, NC, USA.
Rajesh V LallaSection of Oral Medicine, University of Connecticut School of Dental Medicine, Farmington, CT, USA. Electronic address: Lalla@uchc.edu.
Jackson Laboratory · USLevine Cancer Institute · US

Funding

ZONISAMIDE VERSUS PLACEBOM01RR006192 · NCRR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DRAZINIC, CAROLYN M · 1994 to 2008
$22.1M
NCRR NIH HHS M01 RR006192
6 · The paper itself

Abstract

objectiveThe aim of this study was to determine the incidence of bacteremia resulting from dental cleaning and of subsequent established bloodstream infection (BSI) caused by oral microorganisms in patients with cancer with central venous catheters (CVCs). STUDY

designTwenty-six patients with cancer with CVCs and absolute neutrophil count over 1000 cells/µL received dental cleaning without antibiotic prophylaxis. Periodontal status was assessed at baseline by using the Periodontal Screening and Recording (PSR) score. Blood cultures were drawn via the CVCs at baseline, 20 minutes into cleaning, and 30 minutes and 24 hours after cleaning. Medical records were monitored for 6 months.

resultsBaseline blood culture results were negative in 25 patients. Nine of 25 patients (36%) had positive blood culture 20 minutes into cleaning, all associated with at least 1 microorganism typically found in the mouth. These 9 patients had significantly higher mean PSR score (3.22) compared with the other 16 (2.56; P = .035). These expected bacteremias did not persist, with blood culture results (0/25) at 30 minutes and 24 hours after cleaning showing no positivity (P = .001). There were no cases of CVC-related infection or BSI attributable to dental cleaning.

conclusionsBacteremia resulting from dental cleaning is transient and unlikely to cause CVC-related infection or BSI in patients with absolute neutrophil count greater than 1000 cells/µL.

Indexed as

Catheterization, Central VenousAntibiotic ProphylaxisBacteremiaCatheter-Related InfectionsDental ProphylaxisFemaleHumansMaleMiddle AgedNeoplasmsPeriodontal IndexProspective Studies

Identifiers

PMID29428697
PMCPMC5944361
OpenAlexW2783367123

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.