Evidence map›Paper›PMID 29428677›Full record

ArticleMayo Clinic proceedings2018

Association of Resistance Exercise With the Incidence of Hypercholesterolemia in Men.

Esmée A Bakker, Duck-Chul Lee, Xuemei Sui, Thijs M H Eijsvogels, Francisco B Ortega, I-Min Lee, Carl J Lavie, Steven N Blair

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PubMed Full text at PMC Publisher
In one paragraph

Article in Mayo Clinic proceedings, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Review
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  7. Article
  8. The Effects of Exercise on Lipid Biomarkers.Methods in molecular biology (Clifton, N.J.) · 2022
    Review
  9. Article
  10. Observational
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Esmée A BakkerDepartment of Kinesiology, Iowa State University, Ames, IA.
Duck-Chul LeeDepartment of Kinesiology, Iowa State University, Ames, IA. Electronic address: dclee@iastate.edu.
Xuemei SuiDepartment of Exercise Science, University of South Carolina, Columbia, SC.
Thijs M H EijsvogelsDepartment of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands, and Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Francisco B OrtegaDepartment of Physical Education and Sports, University of Granada, Granada, Spain.
I-Min LeeDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, and Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Carl J LavieDepartment of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, University of Queensland School of Medicine, New Orleans, LA.
Steven N BlairDepartment of Exercise Science, University of South Carolina, Columbia, SC.
Iowa State University · USUniversity of South Carolina · USBrigham and Women's Hospital · USLiverpool John Moores University · GBUniversidad de Granada · ES

Funding

Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise (Cardio-RACE)R01HL133069 · NHLBI · IOWA STATE UNIVERSITY · PI LEE, DUCK-CHUL · 2016 to 2020
$3.4M
Impact of Physical Fitness and Exercise on HealthR37AG006945 · NIA · COOPER INSTITUTE · PI BLAIR, STEVEN N. · 2002 to 2005
$2.7M
CORONARY ARTERY CALCIUM, EXERCISE TESTS, AND CHD OUTCOMER01HL062508 · NHLBI · COOPER INSTITUTE · PI LAMONTE, MICHAEL J · 1999 to 2004
$2.5M
IMPACT OF PHYSICAL FITNESS &EXERCISE ON HEALTHR01AG006945 · NIA · COOPER INSTITUTE · PI BLAIR, STEVEN N. · 1986 to 2001
$1.1M
Understanding Patterns of Change in Obesity and Physical Activity in AdultsR21DK088195 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SUI, XUEMEI · 2010 to 2011
$397k
NHLBI NIH HHS R01 HL062508NHLBI NIH HHS R01 HL133069NIA NIH HHS R01 AG006945NIA NIH HHS R37 AG006945NIDDK NIH HHS R21 DK088195
6 · The paper itself

Abstract

objectiveTo examine the associations of resistance exercise, independent of and combined with aerobic exercise, with the risk of development of hypercholesterolemia in men. PATIENTS AND

methodsThis study used data from the Aerobics Center Longitudinal Study, which is a cohort examining the associations of clinical and lifestyle factors with the development of chronic diseases and mortality. Participants received extensive preventive medical examinations at the Cooper Clinic in Dallas, Texas, between January 1, 1987, and December 31, 2006. A total of 7317 men aged 18 to 83 years (mean age, 46 years) without hypercholesterolemia at baseline were included. Frequency (times per week) and total amount (min/wk) of resistance and aerobic exercise were determined by self-report. Hypercholesterolemia was defined as a total cholesterol level of 240 mg/dL or higher or physician diagnosis.

resultsDuring a median (interquartile range) follow-up of 4 (2 to 7) years, hypercholesterolemia developed in 1430 of the 7317 men (20%). Individuals meeting the resistance exercise guidelines (≥2 d/wk) had a 13% lower risk of development of hypercholesterolemia (hazard ratio [HR], 0.87; 95% CI, 0.76-0.99; P=.04) after adjustment for general characteristics, lifestyle factors, and aerobic exercise. In addition, less than 1 h/wk and 2 sessions per week of resistance exercise were associated with 32% and 31% lower risks of hypercholesterolemia (HR, 0.68; 95% CI, 0.54-0.86; P=.001; and HR, 0.69; 95% CI, 0.54-0.88; P=.003), respectively, compared with no resistance exercise. Higher levels of resistance exercise did not provide benefits. Meeting both resistance and aerobic exercise guidelines (≥500 metabolic equivalent task min/wk) lowered the risk of development of hypercholesterolemia by 21% (HR, 0.79; 95% CI, 0.68-0.91; P=.002). compared with meeting none of the guidelines.

conclusionCompared with no resistance exercise, less than 1 h/wk of resistance exercise, independent of aerobic exercise, is associated with a significantly lower risk of development of hypercholesterolemia in men (P=.001). However, the lowest risk of hypercholesterolemia was found at 58 min/wk of resistance exercise. This finding suggests that resistance exercise should be encouraged to prevent hypercholesterolemia in men. However, future studies with a more rigorous analysis including major potential confounders (eg, diet, medications) are warranted.

Indexed as

ExerciseAdultHumansHypercholesterolemiaLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsProspective StudiesResistance TrainingRisk FactorsSelf ReportTime Factors

Identifiers

PMID29428677
PMCPMC5889308
OpenAlexW2786693080

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.