Evidence map›Paper›PMID 29428417›Full record

ArticleCell systems2018

Juicebox.js Provides a Cloud-Based Visualization System for Hi-C Data.

James T Robinson, Douglass Turner, Neva C Durand, Helga Thorvaldsdóttir, Jill P Mesirov, Erez Lieberman Aiden

Abstract read
In one paragraph

Article in Cell systems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 394 papers.

0numbers the graph read from it
0cells of the map it votes in
394citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

394 citing papers in PubMed.

  1. Article
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  3. Reversing aging-like 3D genome disorganization in abioRxiv : the preprint server for biology · 2026
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334 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

James T RobinsonSchool of Medicine, University of California San Diego, La Jolla, CA 92093, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Douglass TurnerSchool of Medicine, University of California San Diego, La Jolla, CA 92093, USA; The Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Neva C DurandBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Center for Theoretical Biological Physics, Rice University, Houston, TX 77030, USA; Department of Computer Science, Rice University, Houston, TX 77030, USA.
Helga ThorvaldsdóttirBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jill P MesirovSchool of Medicine, University of California San Diego, La Jolla, CA 92093, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037, USA.
Erez Lieberman AidenBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Center for Theoretical Biological Physics, Rice University, Houston, TX 77030, USA; Department of Computer Science, Rice University, Houston, TX 77030, USA. Electronic address: erez@erez.com.

Funding

Supporting Integrative Genomic Analysis Users with GenePatternR01GM074024 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESIROV, JILL P. · 2005 to 2019
$6.6M
GENOME WIDE MAPPING OF LOOPS USING IN SITU HI-CUM1HG009375 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI LIEBERMAN-AIDEN, EREZ · 2017 to 2021
$4.7M
The Integrative Genomics Viewer (IGV): visualization supporting cancer researchU24CA210004 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESIROV, JILL P., ROBINSON, JAMES THOMAS · 2016 to 2020
$3.8M
Exploring how the genome folds through proximity ligation and sequencingDP2OD008540 · OD · BROAD INSTITUTE, INC. · PI LIEBERMAN-AIDEN, EREZ · 2011 to 2016
$3.0M
Supplement - Beyond pairwise DNA contacts: exploring higher-order genome structure using proximity ligationU01HL130010 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LIEBERMAN-AIDEN, EREZ · 2015 to 2019
$2.3M
A next-generation Integrative Genomics Viewer for biomedical and cancer research.R01CA157304 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESIROV, JILL P. · 2012 to 2015
$1.9M
NCI NIH HHS R01 CA157304NCI NIH HHS U24 CA210004NHGRI NIH HHS UM1 HG009375NHLBI NIH HHS U01 HL130010NIGMS NIH HHS R01 GM074024NIH HHS DP2 OD008540
6 · The paper itself

Abstract

Contact mapping experiments such as Hi-C explore how genomes fold in 3D. Here, we introduce Juicebox.js, a cloud-based web application for exploring the resulting datasets. Like the original Juicebox application, Juicebox.js allows users to zoom in and out of such datasets using an interface similar to Google Earth. Juicebox.js also has many features designed to facilitate data reproducibility and sharing. Furthermore, Juicebox.js encodes the exact state of the browser in a shareable URL. Creating a public browser for a new Hi-C dataset does not require coding and can be accomplished in under a minute. The web app also makes it possible to create interactive figures online that can complement or replace ordinary journal figures. When combined with Juicer, this makes the entire process of data analysis transparent, insofar as every step from raw reads to published figure is publicly available as open source code.

Indexed as

Cloud ComputingComputational BiologyComputer GraphicsComputersData AnalysisGenomeImage Processing, Computer-AssistedInternetReproducibility of ResultsSoftware3D genomicscontact domainscontact mapenhancersgenome architectureHi-Cloop extrusionloopsnuclear architecturevisualization

Identifiers

PMID29428417
PMCPMC6047755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.