ArticleThe Journal of allergy and clinical immunology2018
Evolution of IgE responses to multiple allergen components throughout childhood.
Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Trajectory Analysis of Pediatric Longitudinal Allergen Sensitization Patterns From Real World Data.Allergy, asthma & immunology research · 2026Article
- Improved Bin-Based Basophil Activation Test Facilitates Comparison of Wheat Allergy and Tolerance in Children and Adults.International journal of molecular sciences · 2026Article
- Molecular sensitization clusters in adult atopy: an ALEXFrontiers in immunology · 2026Article
- Prick test accuracy for Der p components in pediatric rhinitis.European journal of pediatrics · 2025Article
- The Clinical Registry of Childhood Asthma (CRCA) Elucidating Early-Life Asthma: Cross-Sectional Analysis of a Prospective, Longitudinal, and Digitally Enhanced Real-World Cohort.Journal of medical Internet research · 2025Article
- The association of peripheral blood inflammatory markers with the distribution patterns of IgE in children with allergen sensitization.BMC immunology · 2025Article
- Molecular allergen sensitization drives phenotypes of severe asthma in children: Evidence from a megacity cohort (SAMP).Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Inverse association between the molecular spreading of IgE to grass pollen and the IgE response toThe World Allergy Organization journal · 2024Article
- Age-related differences in IgE between childhood and adulthood allergic asthma: Analysis of NHANES 2005-2006.The World Allergy Organization journal · 2023Article
- Novel, computational IgE-clustering in a population-based cross-sectional study: Mapping the allergy burden.Clinical and translational allergy · 2023Article
- Childhood asthma phenotypes and endotypes: a glance into the mosaic.Molecular and cellular pediatrics · 2023Review
- Patterns of aeroallergen sensitization in asthma patients identified by latent class analysis: A cross-sectional study in China.Clinical and translational allergy · 2023Article
- Early-life predictors and risk factors of peanut allergy, and its association with asthma in later-life: Population-based birth cohort study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
- Development of Sensitization to Multiple Allergen Molecules from Preschool to School Age Is Related to Asthma.International archives of allergy and immunology · 2022Article
- Investigation of Allergic Sensitizations in Children With Allergic Rhinitis and/or Asthma.Frontiers in pediatrics · 2022Article
- Identification the Cross-Reactive or Species-Specific Allergens ofDiagnostics (Basel, Switzerland) · 2020Article
- Early-life inhalant allergen exposure, filaggrin genotype, and the development of sensitization from infancy to adolescence.The Journal of allergy and clinical immunology · 2020Article
- IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo.The World Allergy Organization journal · 2020Article
- Microarray-Based Allergy Diagnosis: Quo Vadis?Frontiers in immunology · 2020Review
- The disease burden in patients with respiratory allergies induced by house dust mites: a year-long observational survey in three European countries.Clinical and translational allergy · 2020Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundThere is a paucity of information about longitudinal patterns of IgE responses to allergenic proteins (components) from multiple sources.
objectivesThis study sought to investigate temporal patterns of component-specific IgE responses from infancy to adolescence, and their relationship with allergic diseases.
methodsIn a population-based birth cohort, we measured IgE to 112 components at 6 follow-ups during childhood. We used a Bayesian method to discover cross-sectional sensitization patterns and their longitudinal trajectories, and we related these patterns to asthma and rhinitis in adolescence.
resultsWe identified 1 sensitization cluster at age 1, 3 at age 3, 4 at ages 5 and 8, 5 at age 11, and 6 at age 16 years. "Broad" cluster was the only cluster present at every follow-up, comprising components from multiple sources. "Dust mite" cluster formed at age 3 years and remained unchanged to adolescence. At age 3 years, a single-component "Grass" cluster emerged, which at age 5 years absorbed additional grass components and Fel d 1 to form the "Grass/cat" cluster. Two new clusters formed at age 11 years: "Cat" cluster and "PR-10/profilin" (which divided at age 16 years into "PR-10" and "Profilin"). The strongest contemporaneous associate of asthma at age 16 years was sensitization to dust mite cluster (odds ratio: 2.6; 95% CI: 1.2-6.1; P < .05), but the strongest early life predictor of subsequent asthma was sensitization to grass/cat cluster (odds ratio: 3.5; 95% CI: 1.6-7.4; P < .01).
conclusionsWe describe the architecture of the evolution of IgE responses to multiple allergen components throughout childhood, which may facilitate development of better diagnostic and prognostic biomarkers for allergic diseases.
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