Evidence map›Paper›PMID 29428177›Full record

ArticleVaccine2018

Caregiver and adolescent factors associated with delayed completion of the three-dose human papillomavirus vaccination series.

Lea E Widdice, Rebecca Hoagland, S Todd Callahan, Jessica A Kahn, Christopher J Harrison, Barbara A Pahud, Sharon E Frey, Andrea A Berry, Karen L Kotloff, Kathryn M Edwards and 4 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Vaccine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01030562 (Immunogenicity of the HPV-6, 11, 16, 18 Vaccine Among Adolescent Girls Who Receive Vaccine Doses at Non-recommended Intervals and Factors Related to Non-adherence), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01030562 completednot on this map

Immunogenicity of the HPV-6, 11, 16, 18 Vaccine Among Adolescent Girls Who Receive Vaccine Doses at Non-recommended Intervals and Factors Related to Non-adherence

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2010 to 2014Enrolled1,321ConditionsPapilloma Viral Infection
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Vaccine and Treatment Evaluation Units: A Historical Perspective.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Lea E WiddiceDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 4000, Cincinnati, OH 45229, United States. Electronic address: lea.widdice@cchmc.org.
Rebecca HoaglandCota Enterprises, Inc., 16570 46th Street, McLouth, KS, 66054 , United States. Electronic address: rhoagland@cotaenterprises.com.
S Todd CallahanDivision of Adolescent and Young Adult Health, Vanderbilt University, 719 Thompson Lane Suite 36300, Nashville, TN 37204, United States. Electronic address: todd.callahan@vanderbilt.edu.
Jessica A KahnDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 4000, Cincinnati, OH 45229, United States. Electronic address: jessica.kahn@cchmc.org.
Christopher J HarrisonDivision of Pediatric Infectious Diseases, Children's Mercy Hospital Kansas City, 2401 Gillham Road, Kansas City, MO 64108, United States. Electronic address: cjharrison@cmh.edu.
Barbara A PahudDivision of Pediatric Infectious Diseases, Children's Mercy Hospital Kansas City, 2401 Gillham Road, Kansas City, MO 64108, United States. Electronic address: bpahud@chm.edu.
Sharon E FreyDivision of Infectious Diseases, Allergy and Immunology, Saint Louis University, 1100 S. Grand Boulevard, St. Louis, MO 63104, United States. Electronic address: freyse@slu.edu.
Andrea A BerryDivision of Infectious Diseases and Tropical Pediatrics, Center for Vaccine Development, Institute for Global Health, University of Maryland School of Medicine, 685 W. Baltimore Street, HSF 480, Baltimore, MD 21201, United States. Electronic address: aberry@som.umaryland.edu.
Karen L KotloffDivision of Infectious Diseases and Tropical Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, 685 W. Baltimore Street, HSF 480, Baltimore, MD 21201, United States. Electronic address: kkotloff@som.umaryland.edu.
Kathryn M EdwardsDivision of Pediatric Infectious Diseases, Vanderbilt Vaccine Research Program, D7227 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address: Kathryn.edwards@vanderbilt.edu.
Mark J MulliganThe Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, 500 Irvin Court, Suite 200, Decatur, GA 30030, United States. Electronic address: mark.mulligan@emory.edu.
Jon SudmanKaiser Permanente Georgia, 200 Crescent Centre Parkway, Tucker, GA 30084, United States. Electronic address: jon.sudman@kp.org.
Aya NakamuraThe Emmes Corporation, 401 North Washington Street, Suite 700, Rockville, MD 20850, United States. Electronic address: anakamura@emmes.com.
David I BernsteinDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 4000, Cincinnati, OH 45229, United States. Electronic address: david.bernstein@cchmc.org.
Mercy Hospital · USUniversity of Cincinnati · USUniversity of Maryland, Baltimore · USCincinnati Children's Hospital Medical Center · USEmmes (United States) · USHOPE Clinic · USKaiser Permanente · USSaint Louis University · USVanderbilt University · USVanderbilt University Medical Center · US

Funding

Protein microarray antibody responses to P. falciparum in a human challenge modelK23AI125720 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BERRY, ANDREA · 2017 to 2021
$915k
EVALUATION OF CONTROL MEASURES AGAINST DISEASES OTHER THAN AIDS-266025459N01AI025459 · NIAID · CHILDREN'S HOSPITAL MEDICAL CE · PI BERNSTEIN, DAVID · 2002 to 2006
–
NIAID NIH HHS HHSN272200800003CNIAID NIH HHS HHSN272200800005CNIAID NIH HHS HHSN272200800006CNIAID NIH HHS HHSN272200800007CNIAID NIH HHS HHSN272200800013CNIAID NIH HHS HHSN272201300018INIAID NIH HHS HHSN272201300022INIAID NIH HHS N01 AI025459NIAID NIH HHS N01 AI080006
6 · The paper itself

Abstract

backgroundDelayed completion of human papillomavirus vaccination (4vHPV) series is common. We sought to identify factors associated with delay.

methodsThis substudy was part of a large prospective, multi-site study recruiting 9-17 year old girls at the time of their third 4vHPV dose to assess immunogenicity associated with prolonged dosing intervals. At participating sites, parents/legal guardians (caregivers) of all enrolled girls (9-17 years old) and enrolled girls aged 14-17 years were approached for participation. Caregivers completed a questionnaire measuring adolescent and caregiver sociodemographic characteristics, caregiver attitudes and beliefs about on-schedule HPV vaccination and HPV vaccine safety, adolescent's health behaviors, barriers to accessing health care, provider office vaccination practices and a Rapid Estimate of Adult Literacy in Medicine (REALM). Participating girls completed a separate questionnaire measuring their attitudes and beliefs about on-schedule HPV vaccination and HPV vaccine safety. Delay was defined as receiving the third 4vHPV dose >12 months after the first. Bivariate, multinomial logistic regression and multivariate logistic regression analyses were used to identify factors predicting delayed completion.

resultsQuestionnaires were completed by 482 caregivers and 386 adolescents; 422 caregivers completed a REALM. Delayed 4vHPV dosing occurred in most adolescents (67%). In multivariate analyses, predictors of delayed completion included caregiver demographic factors (self-reported black vs. white race and high school or less education vs. college or more) and an interaction between caregiver's inability to get an immunization appointment as soon as needed and adolescent's type of insurance.

conclusionsCaregiver's race and educational level, accessibility of immunization appointments, and adolescent's insurance type were found to be related to delays in completion of 4vHPV, but caregiver or adolescent attitudes and beliefs about on-schedule HPV vaccination or HPV vaccine safety were not. Therefore, interventions to improve adherence to recommended vaccination schedules could benefit from a focus on improving access to immunizations. ClinicalTrials.gov (NCT01030562).

Indexed as

Immunization ScheduleVaccinationAdolescentAdultAge FactorsCaregiversChildDelivery of Health CareFemaleHealth Knowledge, Attitudes, PracticeHumansImmunogenicity, VaccinePapillomavirus InfectionsPapillomavirus VaccinesPublic Health SurveillancePapillomavirus VaccinesAdherenceCompletionHuman papillomavirusVaccine

Identifiers

PMID29428177
PMCPMC6055999
OpenAlexW2790540083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.